| When | Matchup | Venue |
|---|---|---|
| Chicago Cubs @ Cleveland Guardians Makeup on 4/5 Postponed | Progressive Field | |
| Chicago Cubs @ Cleveland Guardians | Progressive Field | |
| Apr 5Time TBD | Chicago Cubs @ Cleveland Guardians Makeup of 4/4 PPD | Progressive Field |
| Tampa Bay Rays @ Minnesota Twins | Target Field | |
| Chicago Cubs @ Tampa Bay Rays Rays Home Opener this game | Tropicana Field | |
| Chicago Cubs @ Tampa Bay Rays | Tropicana Field | |
| Chicago Cubs @ Tampa Bay Rays | Tropicana Field | |
| Pittsburgh Pirates @ Chicago Cubs | Wrigley Field | |
| New York Yankees @ Tampa Bay Rays | Tropicana Field |