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| Date | Matchup | Venue |
|---|---|---|
| @ San Francisco Giants | Scottsdale Stadium | |
| @ Kansas City Royals | Surprise Stadium | |
| vs San Diego Padres | Sloan Park | |
| vs Colorado Rockies | Sloan Park | |
| @ Los Angeles Angels | Tempe Diablo Stadium | |
| vs Cleveland Guardians | Sloan Park | |
| @ Los Angeles Dodgers | Camelback Ranch | |
| vs Chicago White Sox | Sloan Park | |
| @ Cincinnati Reds | Goodyear Ballpark | |
| vs Italy | Sloan Park | |
| @ Milwaukee Brewers | American Family Fields of Phoenix | |
| vs Arizona Diamondbacks | Sloan Park | |
| @ San Diego Padres | Peoria Stadium | |
| vs Athletics | Sloan Park | |
| vs San Francisco Giants | Sloan Park | |
| @ Texas Rangers | Surprise Stadium | |
| vs Kansas City Royals | Sloan Park | |
| vs Seattle Mariners | Sloan Park | |
| @ Chicago White Sox | Camelback Ranch | |
| @ Colorado Rockies | Salt River Fields at Talking Stick | |
| vs Los Angeles Dodgers | Sloan Park | |
| @ Cleveland Guardians | Goodyear Ballpark | |
| vs Los Angeles Angels | Sloan Park | |
| @ Arizona Diamondbacks | Salt River Fields at Talking Stick | |
| vs Cincinnati Reds | Sloan Park | |
| @ Athletics | Hohokam Stadium | |
| @ Seattle Mariners | Peoria Stadium | |
| vs Milwaukee Brewers | Sloan Park | |
| vs New York Yankees | Sloan Park | |
| vs New York Yankees | Sloan Park | |
| vs Washington Nationals | Wrigley Field | |
| vs Washington Nationals | Wrigley Field | |
| vs Washington Nationals | Wrigley Field | |
| vs Los Angeles Angels | Wrigley Field | |
| vs Los Angeles Angels | Wrigley Field | |
| vs Los Angeles Angels | Wrigley Field | |
| @ Cleveland Guardians | Progressive Field | |
| @ Cleveland Guardians | Progressive Field | |
| @ Cleveland Guardians | Progressive Field | |
| @ Tampa Bay Rays | Tropicana Field | |
| @ Tampa Bay Rays | Tropicana Field | |
| @ Tampa Bay Rays | Tropicana Field | |
| vs Pittsburgh Pirates | Wrigley Field | |
| vs Pittsburgh Pirates | Wrigley Field | |
| vs Pittsburgh Pirates | Wrigley Field | |
| @ Philadelphia Phillies | Citizens Bank Park | |
| @ Philadelphia Phillies | Citizens Bank Park | |
| @ Philadelphia Phillies | Citizens Bank Park | |
| vs New York Mets | Wrigley Field | |
| vs New York Mets | Wrigley Field | |
| vs New York Mets | Wrigley Field | |
| vs Philadelphia Phillies | Wrigley Field | |
| vs Philadelphia Phillies | Wrigley Field | |
| vs Philadelphia Phillies | Wrigley Field | |
| vs Philadelphia Phillies | Wrigley Field | |
| @ Los Angeles Dodgers | Dodger Stadium | |
| @ Los Angeles Dodgers | Dodger Stadium | |
| @ Los Angeles Dodgers | Dodger Stadium | |
| @ San Diego Padres | Petco Park | |
| @ San Diego Padres | Petco Park | |
| @ San Diego Padres | Petco Park | |
| vs Arizona Diamondbacks | Wrigley Field | |
| vs Arizona Diamondbacks | Wrigley Field | |
| vs Arizona Diamondbacks | Wrigley Field | |
| vs Cincinnati Reds | Wrigley Field | |
| vs Cincinnati Reds | Wrigley Field | |
| vs Cincinnati Reds | Wrigley Field | |
| vs Cincinnati Reds | Wrigley Field | |
| @ Texas Rangers | Globe Life Field | |
| @ Texas Rangers | Globe Life Field | |
| @ Texas Rangers | Globe Life Field | |
| @ Atlanta Braves | Truist Park | |
| @ Atlanta Braves | Truist Park | |
| @ Atlanta Braves | Truist Park | |
| @ Chicago White Sox | Rate Field | |
| @ Chicago White Sox | Rate Field | |
| @ Chicago White Sox | Rate Field | |
| vs Milwaukee Brewers | Wrigley Field | |
| vs Milwaukee Brewers | Wrigley Field | |
| vs Milwaukee Brewers | Wrigley Field | |
| vs Houston Astros | Wrigley Field | |
| vs Houston Astros | Wrigley Field | |
| vs Houston Astros | Wrigley Field | |
| @ Pittsburgh Pirates | PNC Park | |
| @ Pittsburgh Pirates | PNC Park | |
| @ Pittsburgh Pirates | PNC Park | |
| @ Pittsburgh Pirates | PNC Park | |
| @ St. Louis Cardinals | Busch Stadium | |
| @ St. Louis Cardinals | Busch Stadium | |
| @ St. Louis Cardinals | Busch Stadium | |
| vs Athletics | Wrigley Field | |
| vs Athletics | Wrigley Field | |
| vs Athletics | Wrigley Field | |
| vs San Francisco Giants | Wrigley Field | |
| vs San Francisco Giants | Wrigley Field | |
| vs San Francisco Giants | Wrigley Field | |
| @ Colorado Rockies | Coors Field | |
| @ Colorado Rockies | Coors Field | |
| @ Colorado Rockies | Coors Field | |
| @ San Francisco Giants | Oracle Park | |
| @ San Francisco Giants | Oracle Park | |
| @ San Francisco Giants | Oracle Park | |
| vs Colorado Rockies | Wrigley Field | |
| vs Colorado Rockies | Wrigley Field | |
| vs Colorado Rockies | Wrigley Field | |
| vs Toronto Blue Jays | Wrigley Field | |
| vs Toronto Blue Jays | Wrigley Field | |
| vs Toronto Blue Jays | Wrigley Field | |
| @ New York Mets | Citi Field | |
| @ New York Mets | Citi Field | |
| @ New York Mets | Citi Field | |
| @ New York Mets | Citi Field | |
| @ Milwaukee Brewers | American Family Field | |
| @ Milwaukee Brewers | American Family Field | |
| @ Milwaukee Brewers | American Family Field | |
| vs San Diego Padres | Wrigley Field | |
| vs San Diego Padres | Wrigley Field | |
| vs San Diego Padres | Wrigley Field | |
| vs St. Louis Cardinals | Wrigley Field | |
| vs St. Louis Cardinals | Wrigley Field | |
| vs St. Louis Cardinals | Wrigley Field | |
| @ Baltimore Orioles | Oriole Park at Camden Yards | |
| @ Baltimore Orioles | Oriole Park at Camden Yards | |
| @ Baltimore Orioles | Oriole Park at Camden Yards | |
| @ Cincinnati Reds | Great American Ball Park | |
| @ Cincinnati Reds | Great American Ball Park | |
| @ Cincinnati Reds | Great American Ball Park | |
| vs Minnesota Twins | Wrigley Field | |
| vs Minnesota Twins | Wrigley Field | |
| vs Minnesota Twins | Wrigley Field | |
| vs Detroit Tigers | Wrigley Field | |
| vs Detroit Tigers | Wrigley Field | |
| vs Detroit Tigers | Wrigley Field | |
| @ Pittsburgh Pirates | PNC Park | |
| @ Pittsburgh Pirates | PNC Park | |
| @ Pittsburgh Pirates | PNC Park | |
| @ St. Louis Cardinals | Busch Stadium | |
| @ St. Louis Cardinals | Busch Stadium | |
| @ St. Louis Cardinals | Busch Stadium | |
| @ St. Louis Cardinals | Busch Stadium | |
| vs New York Yankees | Wrigley Field | |
| vs New York Yankees | Wrigley Field | |
| vs New York Yankees | Wrigley Field | |
| vs Los Angeles Dodgers | Wrigley Field | |
| vs Los Angeles Dodgers | Wrigley Field | |
| vs Los Angeles Dodgers | Wrigley Field | |
| @ Kansas City Royals | Kauffman Stadium | |
| @ Kansas City Royals | Kauffman Stadium | |
| @ Kansas City Royals | Kauffman Stadium | |
| @ Washington Nationals | Nationals Park | |
| @ Washington Nationals | Nationals Park | |
| @ Washington Nationals | Nationals Park | |
| vs St. Louis Cardinals | Wrigley Field | |
| vs St. Louis Cardinals | Wrigley Field | |
| vs St. Louis Cardinals | Wrigley Field | |
| vs Chicago White Sox | Wrigley Field | |
| vs Chicago White Sox | Wrigley Field | |
| vs Chicago White Sox | Wrigley Field | |
| @ Seattle Mariners | T-Mobile Park | |
| @ Seattle Mariners | T-Mobile Park | |
| @ Seattle Mariners | T-Mobile Park | |
| @ Arizona Diamondbacks | Chase Field | |
| @ Arizona Diamondbacks | Chase Field | |
| @ Arizona Diamondbacks | Chase Field | |
| vs Cincinnati Reds | Wrigley Field | |
| vs Cincinnati Reds | Wrigley Field | |
| vs Cincinnati Reds | Wrigley Field | |
| vs Milwaukee Brewers | Wrigley Field | |
| vs Milwaukee Brewers | Wrigley Field | |
| vs Milwaukee Brewers | Wrigley Field | |
| vs Milwaukee Brewers | Wrigley Field | |
| @ Miami Marlins | loanDepot park | |
| @ Miami Marlins | loanDepot park | |
| @ Miami Marlins | loanDepot park | |
| @ Milwaukee Brewers | American Family Field | |
| @ Milwaukee Brewers | American Family Field | |
| @ Milwaukee Brewers | American Family Field | |
| vs Pittsburgh Pirates | Wrigley Field | |
| vs Pittsburgh Pirates | Wrigley Field | |
| vs Pittsburgh Pirates | Wrigley Field | |
| vs Atlanta Braves | Wrigley Field | |
| vs Atlanta Braves | Wrigley Field | |
| vs Atlanta Braves | Wrigley Field | |
| @ Cincinnati Reds | Great American Ball Park | |
| @ Cincinnati Reds | Great American Ball Park | |
| @ Cincinnati Reds | Great American Ball Park | |
| vs Miami Marlins | Wrigley Field | |
| vs Miami Marlins | Wrigley Field | |
| vs Miami Marlins | Wrigley Field | |
| @ Boston Red Sox | Fenway Park | |
| @ Boston Red Sox | Fenway Park | |
| @ Boston Red Sox | Fenway Park |