| When | Matchup | Venue |
|---|---|---|
| Charleston RiverDogs @ Hickory Crawdads Game moved to Truist Stadium in Winston-Salem | Truist Stadium | |
| Charleston RiverDogs @ Hickory Crawdads Game moved to Truist Stadium in Winston-Salem | Truist Stadium | |
| Charleston RiverDogs @ Hickory Crawdads Game moved to Truist Stadium in Winston-Salem Postponed | Truist Stadium | |
| Charleston RiverDogs @ Hickory Crawdads Game moved to Truist Stadium in Winston-Salem | Truist Stadium | |
| May 24Time TBD | Charleston RiverDogs @ Hickory Crawdads Game in Winston-Salem; Makeup of 5/23 PPD this game | Truist Stadium |
| Hickory Crawdads @ Salem RidgeYaks | Carilion Clinic Field | |
| Charleston RiverDogs @ Columbia Fireflies Postponed | Prisma Health Park | |
| Charleston RiverDogs @ Columbia Fireflies | Prisma Health Park | |
| May 27Time TBD | Charleston RiverDogs @ Columbia Fireflies Makeup of 5/26 PPD Postponed | Prisma Health Park |