| Sep 10 | @ Fenerbahce | Şükrü Saracoğlu Stadium, IstanbulCBSSN, Paramount+ |
| Oct 14 | vs Real Madrid | Olimpico, RomaParamount+ |
| Oct 20 | vs Slovan Bratislava | Olimpico, RomaParamount+ |
| Nov 3 | @ Manchester United | Old Trafford, ManchesterParamount+ |
| When | Matchup | Venue and broadcast |
|---|---|---|
| Nov 25 | @ Paris Saint-Germain | Parc des Princes, ParisParamount+ |
| Dec 8 | vs Sporting CP | Olimpico, RomaParamount+ |
| Jan 19 | @ AEK Athens | OPAP Arena, AthensParamount+ |
| Jan 27 | vs Lille | Olimpico, RomaParamount+ |