| Sep 9 | vs Arsenal | Stadio Diego Armando Maradona, NapoliParamount+ |
| Oct 13 | @ Villarreal | Estadio de la Cerámica, VillarrealParamount+ |
| Oct 20 | vs Bodo/Glimt | Stadio Diego Armando Maradona, NapoliParamount+ |
| When | Matchup | Venue and broadcast |
|---|---|---|
| Nov 4 | @ FC Porto | Estádio do Dragão, PortoCBSSN, Paramount+ |
| Nov 24 | @ Manchester City | Etihad Stadium, ManchesterParamount+ |
| Dec 8 | vs Club Brugge | Stadio Diego Armando Maradona, NapoliParamount+ |
| Jan 20 | @ Sabah FK | Baku Olympic Stadium, BakuParamount+ |
| Jan 27 | vs Viking FK | Stadio Diego Armando Maradona, NapoliParamount+ |