| Sep 10 | vs Sabah FK | Old Trafford, ManchesterParamount+ |
| Oct 13 | @ Atlético Madrid | Riyadh Air Metropolitano, MadridParamount+ |
| Oct 21 | @ Como | Giuseppe Sinigaglia, ComoParamount+ |
| Nov 3 | vs AS Roma | Old Trafford, ManchesterParamount+ |
| When | Matchup | Venue and broadcast |
|---|---|---|
| Nov 25 | @ Sporting CP | Estádio José Alvalade, LisbonParamount+ |
| Dec 8 | vs RB Leipzig | Old Trafford, ManchesterParamount+ |
| Jan 20 | vs Bayern Munich | Old Trafford, ManchesterParamount+ |
| Jan 27 | @ Villarreal | Estadio de la Cerámica, VillarrealParamount+ |