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| Date | Matchup | Venue |
|---|---|---|
| vs Boston Celtics | Rocket Arena, Cleveland, OH | |
| vs Orlando Magic | Rocket Arena, Cleveland, OH | |
| @ Orlando Magic | Kia Center, Orlando, FL | |
| @ Philadelphia 76ers | Xfinity Mobile Arena, Philadelphia, PA | |
| vs Brooklyn Nets | Rocket Arena, Cleveland, OH | |
| vs Minnesota Timberwolves | Rocket Arena, Cleveland, OH | |
| vs Washington Wizards | Rocket Arena, Cleveland, OH | |
| @ Atlanta Hawks | State Farm Arena, Atlanta, GA | |
| @ Milwaukee Bucks | Fiserv Forum, Milwaukee, WI | |
| vs Oklahoma City Thunder | Rocket Arena, Cleveland, OH | |
| @ Oklahoma City Thunder | Paycom Center, Oklahoma City, OK | |
| vs Philadelphia 76ers East Group B | Rocket Arena, Cleveland, OH | |
| vs New York Knicks | Rocket Arena, Cleveland, OH | |
| @ Charlotte Hornets | Spectrum Center, Charlotte, NC | |
| @ New York Knicks | Madison Square Garden, New York, NY | |
| @ Miami Heat East Group B | Kaseya Center, Miami, FL | |
| vs Dallas Mavericks | Rocket Arena, Cleveland, OH | |
| vs Chicago Bulls | Rocket Arena, Cleveland, OH | |
| vs Memphis Grizzlies | Rocket Arena, Cleveland, OH | |
| vs Indiana Pacers East Group B | Rocket Arena, Cleveland, OH | |
| @ Chicago Bulls | United Center, Chicago, IL | |
| @ New York Knicks East Group B | Madison Square Garden, New York, NY | |
| vs Miami Heat | Rocket Arena, Cleveland, OH | |
| vs Indiana Pacers | Rocket Arena, Cleveland, OH | |
| @ Chicago Bulls | United Center, Chicago, IL | |
| vs Golden State Warriors | Rocket Arena, Cleveland, OH | |
| vs San Antonio Spurs | Rocket Arena, Cleveland, OH | |
| @ Orlando Magic | Kia Center, Orlando, FL | |
| @ Detroit Pistons | Little Caesars Arena, Detroit, MI | |
| vs Utah Jazz | Rocket Arena, Cleveland, OH | |
| vs New York Knicks | Rocket Arena, Cleveland, OH | |
| @ Washington Wizards | Capital One Arena, Washington, DC | |
| vs Washington Wizards | Rocket Arena, Cleveland, OH | |
| @ Boston Celtics | TD Garden, Boston, MA | |
| vs LA Clippers | Rocket Arena, Cleveland, OH | |
| @ Charlotte Hornets | Spectrum Center, Charlotte, NC | |
| @ Houston Rockets | Toyota Center, Houston, TX | |
| vs Toronto Raptors | Rocket Arena, Cleveland, OH | |
| @ Orlando Magic | Kia Center, Orlando, FL | |
| vs Denver Nuggets | Rocket Arena, Cleveland, OH | |
| @ Minnesota Timberwolves | Target Center, Minneapolis, MN | |
| @ Atlanta Hawks | State Farm Arena, Atlanta, GA | |
| @ Milwaukee Bucks | Fiserv Forum, Milwaukee, WI | |
| @ Memphis Grizzlies | FedExForum, Memphis, TN | |
| vs Detroit Pistons | Rocket Arena, Cleveland, OH | |
| @ Brooklyn Nets | Barclays Center, Brooklyn, NY | |
| @ Dallas Mavericks | American Airlines Center, Dallas, TX | |
| @ New Orleans Pelicans | Smoothie King Center, New Orleans, LA | |
| vs Detroit Pistons | Rocket Arena, Cleveland, OH | |
| @ Toronto Raptors | Scotiabank Arena, Toronto, ON | |
| vs New Orleans Pelicans | Rocket Arena, Cleveland, OH | |
| @ Utah Jazz | Delta Center, Salt Lake City, UT | |
| @ Phoenix Suns | Mortgage Matchup Center, Phoenix, AZ | |
| @ Portland Trail Blazers | Moda Center, Portland, OR | |
| vs Orlando Magic | Rocket Arena, Cleveland, OH | |
| vs Toronto Raptors | Rocket Arena, Cleveland, OH | |
| @ Indiana Pacers | Gainbridge Fieldhouse, Indianapolis, IN | |
| @ Toronto Raptors | Scotiabank Arena, Toronto, ON | |
| vs Phoenix Suns | Rocket Arena, Cleveland, OH | |
| vs Milwaukee Bucks | Rocket Arena, Cleveland, OH | |
| vs Milwaukee Bucks | Rocket Arena, Cleveland, OH | |
| vs Sacramento Kings | Rocket Arena, Cleveland, OH | |
| @ Boston Celtics | TD Garden, Boston, MA | |
| vs Philadelphia 76ers | Rocket Arena, Cleveland, OH | |
| vs Portland Trail Blazers | Rocket Arena, Cleveland, OH | |
| vs Atlanta Hawks | Rocket Arena, Cleveland, OH | |
| @ Detroit Pistons | Little Caesars Arena, Detroit, MI | |
| @ LA Clippers | Intuit Dome, Inglewood, CA | |
| @ Los Angeles Lakers | Crypto.com Arena, Los Angeles, CA | |
| @ Sacramento Kings | Golden 1 Center, Sacramento, CA | |
| @ Golden State Warriors | Chase Center, San Francisco, CA | |
| @ Denver Nuggets | Ball Arena, Denver, CO | |
| vs Chicago Bulls | Rocket Arena, Cleveland, OH | |
| vs Houston Rockets | Rocket Arena, Cleveland, OH | |
| vs Los Angeles Lakers | Rocket Arena, Cleveland, OH | |
| vs Miami Heat | Rocket Arena, Cleveland, OH | |
| @ Brooklyn Nets | Barclays Center, Brooklyn, NY | |
| vs Boston Celtics | Rocket Arena, Cleveland, OH | |
| vs Charlotte Hornets | Rocket Arena, Cleveland, OH | |
| vs Brooklyn Nets | Rocket Arena, Cleveland, OH | |
| @ San Antonio Spurs | Frost Bank Center, San Antonio, TX | |
| @ Indiana Pacers | Gainbridge Fieldhouse, Indianapolis, IN | |
| vs Atlanta Hawks | Rocket Arena, Cleveland, OH |