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| Date | Matchup | Venue |
|---|---|---|
| @ Tampa Bay Rays | Tropicana Field | |
| @ Tampa Bay Rays | Tropicana Field | |
| vs Philadelphia Phillies | Nationals Park | |
| vs Philadelphia Phillies | Nationals Park | |
| vs Philadelphia Phillies | Nationals Park | |
| vs Philadelphia Phillies | Nationals Park | |
| @ Baltimore Orioles | Oriole Park at Camden Yards | |
| @ Baltimore Orioles | Oriole Park at Camden Yards | |
| @ Baltimore Orioles | Oriole Park at Camden Yards | |
| @ Boston Red Sox | Fenway Park | |
| @ Boston Red Sox | Fenway Park | |
| @ Boston Red Sox | Fenway Park | |
| vs Pittsburgh Pirates | Nationals Park | |
| vs Pittsburgh Pirates | Nationals Park | |
| vs Pittsburgh Pirates | Nationals Park | |
| vs Houston Astros | Nationals Park | |
| vs Houston Astros | Nationals Park | |
| vs Houston Astros | Nationals Park | |
| vs New York Yankees | Nationals Park | |
| vs New York Yankees | Nationals Park | |
| vs New York Yankees | Nationals Park | |
| @ Athletics | Sutter Health Park | |
| @ Athletics | Sutter Health Park | |
| @ Athletics | Sutter Health Park | |
| @ Colorado Rockies | Coors Field | |
| @ Colorado Rockies | Coors Field | |
| @ Colorado Rockies | Coors Field | |
| vs Arizona Diamondbacks | Nationals Park | |
| vs Arizona Diamondbacks | Nationals Park | |
| vs Arizona Diamondbacks | Nationals Park | |
| vs Toronto Blue Jays | Nationals Park | |
| vs Toronto Blue Jays | Nationals Park | |
| vs Toronto Blue Jays | Nationals Park | |
| @ Atlanta Braves | Truist Park | |
| @ Atlanta Braves | Truist Park | |
| @ Atlanta Braves | Truist Park | |
| @ Atlanta Braves | Truist Park | |
| @ Philadelphia Phillies | Citizens Bank Park | |
| @ Philadelphia Phillies | Citizens Bank Park | |
| @ Philadelphia Phillies | Citizens Bank Park | |
| @ Philadelphia Phillies | Citizens Bank Park | |
| vs Cincinnati Reds | Nationals Park | |
| vs Cincinnati Reds | Nationals Park | |
| vs Cincinnati Reds | Nationals Park | |
| vs Chicago Cubs | Nationals Park | |
| vs Chicago Cubs | Nationals Park | |
| vs Chicago Cubs | Nationals Park | |
| @ New York Mets | Citi Field | |
| @ New York Mets | Citi Field | |
| @ New York Mets | Citi Field | |
| @ Texas Rangers | Globe Life Field | |
| @ Texas Rangers | Globe Life Field | |
| @ Texas Rangers | Globe Life Field | |
| @ Miami Marlins | loanDepot park | |
| @ Miami Marlins | loanDepot park | |
| @ Miami Marlins | loanDepot park | |
| vs Colorado Rockies | Nationals Park | |
| vs Colorado Rockies | Nationals Park | |
| vs Colorado Rockies | Nationals Park | |
| vs Colorado Rockies | Nationals Park | |
| vs Miami Marlins | Nationals Park | |
| vs Miami Marlins | Nationals Park | |
| vs Miami Marlins | Nationals Park | |
| vs Miami Marlins | Nationals Park | |
| vs Atlanta Braves | Nationals Park | |
| vs Atlanta Braves | Nationals Park | |
| @ Los Angeles Dodgers | UNIQLO Field at Dodger Stadium | |
| @ Los Angeles Dodgers | UNIQLO Field at Dodger Stadium | |
| @ Los Angeles Dodgers | UNIQLO Field at Dodger Stadium | |
| @ San Diego Padres | Petco Park | |
| @ San Diego Padres | Petco Park | |
| @ San Diego Padres | Petco Park | |
| vs Los Angeles Angels | Nationals Park | |
| vs Los Angeles Angels | Nationals Park | |
| vs Los Angeles Angels | Nationals Park | |
| vs Philadelphia Phillies Roberto Clemente Day | Nationals Park | |
| vs Philadelphia Phillies | Nationals Park | |
| @ St. Louis Cardinals | Busch Stadium | |
| @ St. Louis Cardinals | Busch Stadium | |
| @ St. Louis Cardinals | Busch Stadium | |
| @ Detroit Tigers | Comerica Park | |
| @ Detroit Tigers | Comerica Park | |
| @ Detroit Tigers | Comerica Park | |
| vs New York Mets | Nationals Park | |
| vs New York Mets | Nationals Park | |
| vs New York Mets | Nationals Park |