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| Date | Matchup | Venue |
|---|---|---|
| @ Colorado Rockies | Coors Field | |
| @ Colorado Rockies | Coors Field | |
| @ Colorado Rockies | Coors Field | |
| @ Arizona Diamondbacks Mexico City Series | Estadio Alfredo Harp Helu | |
| @ Arizona Diamondbacks Mexico City Series | Estadio Alfredo Harp Helu | |
| vs Chicago Cubs | Petco Park | |
| vs Chicago Cubs | Petco Park | |
| vs Chicago Cubs | Petco Park | |
| vs Chicago White Sox | Petco Park | |
| vs Chicago White Sox | Petco Park | |
| vs Chicago White Sox | Petco Park | |
| @ San Francisco Giants | Oracle Park | |
| @ San Francisco Giants | Oracle Park | |
| @ San Francisco Giants | Oracle Park | |
| vs St. Louis Cardinals | Petco Park | |
| vs St. Louis Cardinals | Petco Park | |
| vs St. Louis Cardinals | Petco Park | |
| vs St. Louis Cardinals | Petco Park | |
| @ Milwaukee Brewers | American Family Field | |
| @ Milwaukee Brewers | American Family Field | |
| @ Milwaukee Brewers | American Family Field | |
| @ Seattle Mariners | T-Mobile Park | |
| @ Seattle Mariners | T-Mobile Park | |
| @ Seattle Mariners | T-Mobile Park | |
| vs Los Angeles Dodgers | Petco Park | |
| vs Los Angeles Dodgers | Petco Park | |
| vs Los Angeles Dodgers | Petco Park | |
| vs Athletics | Petco Park | |
| vs Athletics | Petco Park | |
| vs Athletics | Petco Park | |
| vs Philadelphia Phillies | Petco Park | |
| vs Philadelphia Phillies | Petco Park | |
| vs Philadelphia Phillies | Petco Park | |
| @ Washington Nationals | Nationals Park | |
| @ Washington Nationals | Nationals Park | |
| @ Washington Nationals | Nationals Park | |
| @ Philadelphia Phillies Lou Gehrig Day | Citizens Bank Park | |
| @ Philadelphia Phillies | Citizens Bank Park | |
| @ Philadelphia Phillies | Citizens Bank Park | |
| vs New York Mets | Petco Park | |
| vs New York Mets | Petco Park | |
| vs New York Mets | Petco Park | |
| vs Cincinnati Reds | Petco Park | |
| vs Cincinnati Reds | Petco Park | |
| vs Cincinnati Reds | Petco Park | |
| @ Baltimore Orioles | Oriole Park at Camden Yards | |
| @ Baltimore Orioles | Oriole Park at Camden Yards | |
| @ Baltimore Orioles | Oriole Park at Camden Yards | |
| @ St. Louis Cardinals | Busch Stadium | |
| @ St. Louis Cardinals | Busch Stadium | |
| @ St. Louis Cardinals | Busch Stadium | |
| @ Texas Rangers | Globe Life Field | |
| @ Texas Rangers | Globe Life Field | |
| @ Texas Rangers | Globe Life Field | |
| vs Atlanta Braves | Petco Park | |
| vs Atlanta Braves | Petco Park | |
| vs Atlanta Braves | Petco Park | |
| vs Los Angeles Dodgers | Petco Park | |
| vs Los Angeles Dodgers | Petco Park | |
| vs Los Angeles Dodgers | Petco Park | |
| @ Chicago Cubs | Wrigley Field | |
| @ Chicago Cubs | Wrigley Field | |
| @ Chicago Cubs | Wrigley Field | |
| @ Los Angeles Dodgers | UNIQLO Field at Dodger Stadium | |
| @ Los Angeles Dodgers | UNIQLO Field at Dodger Stadium | |
| @ Los Angeles Dodgers | UNIQLO Field at Dodger Stadium | |
| @ Los Angeles Dodgers | UNIQLO Field at Dodger Stadium | |
| vs Arizona Diamondbacks | Petco Park | |
| vs Arizona Diamondbacks | Petco Park | |
| vs Arizona Diamondbacks | Petco Park | |
| vs Arizona Diamondbacks | Petco Park | |
| vs Toronto Blue Jays | Petco Park | |
| vs Toronto Blue Jays | Petco Park | |
| vs Toronto Blue Jays | Petco Park | |
| @ Kansas City Royals | Kauffman Stadium | |
| @ Kansas City Royals | Kauffman Stadium | |
| @ Kansas City Royals | Kauffman Stadium | |
| @ Atlanta Braves | Truist Park | |
| @ Atlanta Braves | Truist Park | |
| @ Atlanta Braves | Truist Park | |
| @ Atlanta Braves | Truist Park | |
| @ Miami Marlins | loanDepot park | |
| @ Miami Marlins | loanDepot park | |
| @ Miami Marlins | loanDepot park | |
| vs Colorado Rockies | Petco Park | |
| vs Colorado Rockies | Petco Park | |
| vs San Francisco Giants | Petco Park | |
| vs San Francisco Giants | Petco Park | |
| vs San Francisco Giants | Petco Park | |
| vs San Francisco Giants | Petco Park | |
| @ Arizona Diamondbacks | Chase Field | |
| @ Arizona Diamondbacks | Chase Field | |
| @ Arizona Diamondbacks | Chase Field | |
| @ Arizona Diamondbacks | Chase Field | |
| vs Houston Astros | Petco Park | |
| vs Houston Astros | Petco Park | |
| vs Houston Astros | Petco Park | |
| vs Milwaukee Brewers | Petco Park | |
| vs Milwaukee Brewers | Petco Park | |
| vs Milwaukee Brewers | Petco Park | |
| @ Cleveland Guardians | Progressive Field | |
| @ Cleveland Guardians | Progressive Field | |
| @ Cleveland Guardians | Progressive Field | |
| @ New York Mets | Citi Field | |
| @ New York Mets | Citi Field | |
| @ New York Mets | Citi Field | |
| vs Minnesota Twins | Petco Park | |
| vs Minnesota Twins | Petco Park | |
| vs Minnesota Twins | Petco Park | |
| vs Pittsburgh Pirates | Petco Park | |
| vs Pittsburgh Pirates | Petco Park | |
| vs Pittsburgh Pirates | Petco Park | |
| @ Tampa Bay Rays | Tropicana Field | |
| @ Tampa Bay Rays | Tropicana Field | |
| @ Tampa Bay Rays | Tropicana Field | |
| @ Cincinnati Reds | Great American Ball Park | |
| @ Cincinnati Reds | Great American Ball Park | |
| @ Cincinnati Reds | Great American Ball Park | |
| vs New York Yankees | Petco Park | |
| vs New York Yankees | Petco Park | |
| vs New York Yankees | Petco Park | |
| vs Washington Nationals | Petco Park | |
| vs Washington Nationals | Petco Park | |
| vs Washington Nationals | Petco Park | |
| @ San Francisco Giants | Oracle Park | |
| @ San Francisco Giants | Oracle Park | |
| @ San Francisco Giants | Oracle Park | |
| @ Colorado Rockies | Coors Field | |
| @ Colorado Rockies Roberto Clemente Day | Coors Field | |
| @ Colorado Rockies | Coors Field | |
| @ Colorado Rockies | Coors Field | |
| vs Miami Marlins | Petco Park | |
| vs Miami Marlins | Petco Park | |
| vs Miami Marlins | Petco Park | |
| @ Los Angeles Dodgers | UNIQLO Field at Dodger Stadium | |
| @ Los Angeles Dodgers | UNIQLO Field at Dodger Stadium | |
| @ Los Angeles Dodgers | UNIQLO Field at Dodger Stadium | |
| vs Arizona Diamondbacks | Petco Park | |
| vs Arizona Diamondbacks | Petco Park | |
| vs Arizona Diamondbacks | Petco Park | |