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| Date | Matchup | Venue |
|---|---|---|
| vs Baltimore Orioles | Publix Field at Joker Marchant Stadium | |
| vs Minnesota Twins | Publix Field at Joker Marchant Stadium | |
| @ Atlanta Braves | CoolToday Park | |
| vs Toronto Blue Jays | Publix Field at Joker Marchant Stadium | |
| @ Philadelphia Phillies | BayCare Ballpark | |
| @ Baltimore Orioles | Ed Smith Stadium | |
| vs Philadelphia Phillies | Publix Field at Joker Marchant Stadium | |
| @ Tampa Bay Rays | Charlotte Sports Park | |
| vs Toronto Blue Jays | Publix Field at Joker Marchant Stadium | |
| vs Atlanta Braves | Publix Field at Joker Marchant Stadium | |
| @ Dominican Republic | Estadio Quisqueya Juan Marichal | |
| vs Panama | Publix Field at Joker Marchant Stadium | |
| @ Dominican Republic | Estadio Quisqueya Juan Marichal | |
| vs Boston Red Sox | Publix Field at Joker Marchant Stadium | |
| vs Pittsburgh Pirates | Publix Field at Joker Marchant Stadium | |
| @ Toronto Blue Jays | TD Ballpark | |
| vs Tampa Bay Rays | Publix Field at Joker Marchant Stadium | |
| @ Boston Red Sox | JetBlue Park | |
| @ Minnesota Twins | Lee Health Sports Complex | |
| vs New York Yankees | Publix Field at Joker Marchant Stadium | |
| vs Pittsburgh Pirates | Publix Field at Joker Marchant Stadium | |
| @ Toronto Blue Jays | TD Ballpark | |
| @ New York Yankees | George M. Steinbrenner Field | |
| vs Philadelphia Phillies | Publix Field at Joker Marchant Stadium | |
| vs Baltimore Orioles | Publix Field at Joker Marchant Stadium | |
| @ Pittsburgh Pirates | LECOM Park | |
| @ Philadelphia Phillies | BayCare Ballpark | |
| vs New York Yankees | Publix Field at Joker Marchant Stadium | |
| @ Colorado Rockies | Salt River Fields at Talking Stick | |
| @ Colorado Rockies | Salt River Fields at Talking Stick | |
| @ San Diego Padres | Petco Park | |
| @ San Diego Padres | Petco Park | |
| @ San Diego Padres | Petco Park | |
| @ Arizona Diamondbacks | Chase Field | |
| @ Arizona Diamondbacks | Chase Field | |
| @ Arizona Diamondbacks | Chase Field | |
| vs St. Louis Cardinals | Comerica Park | |
| vs St. Louis Cardinals | Comerica Park | |
| vs St. Louis Cardinals | Comerica Park | |
| @ Minnesota Twins | Target Field | |
| @ Minnesota Twins | Target Field | |
| @ Minnesota Twins | Target Field | |
| @ Minnesota Twins | Target Field | |
| vs Miami Marlins | Comerica Park | |
| vs Miami Marlins | Comerica Park | |
| vs Miami Marlins | Comerica Park | |
| vs Kansas City Royals | Comerica Park | |
| vs Kansas City Royals | Comerica Park | |
| vs Kansas City Royals | Comerica Park | |
| @ Boston Red Sox | Fenway Park | |
| @ Boston Red Sox | Fenway Park | |
| @ Boston Red Sox | Fenway Park | |
| @ Boston Red Sox | Fenway Park | |
| vs Milwaukee Brewers | Comerica Park | |
| vs Milwaukee Brewers | Comerica Park | |
| vs Milwaukee Brewers | Comerica Park | |
| @ Cincinnati Reds | Great American Ball Park | |
| @ Cincinnati Reds | Great American Ball Park | |
| @ Cincinnati Reds | Great American Ball Park | |
| @ Atlanta Braves | Truist Park | |
| @ Atlanta Braves | Truist Park | |
| @ Atlanta Braves | Truist Park | |
| vs Texas Rangers | Comerica Park | |
| vs Texas Rangers | Comerica Park | |
| vs Texas Rangers | Comerica Park | |
| vs Boston Red Sox | Comerica Park | |
| vs Boston Red Sox | Comerica Park | |
| vs Boston Red Sox | Comerica Park | |
| @ Kansas City Royals | Kauffman Stadium | |
| @ Kansas City Royals | Kauffman Stadium | |
| @ Kansas City Royals | Kauffman Stadium | |
| @ New York Mets | Citi Field | |
| @ New York Mets | Citi Field | |
| @ New York Mets | Citi Field | |
| vs Toronto Blue Jays | Comerica Park | |
| vs Toronto Blue Jays | Comerica Park | |
| vs Toronto Blue Jays | Comerica Park | |
| vs Cleveland Guardians | Comerica Park | |
| vs Cleveland Guardians | Comerica Park | |
| vs Cleveland Guardians | Comerica Park | |
| vs Cleveland Guardians | Comerica Park | |
| @ Baltimore Orioles | Oriole Park at Camden Yards | |
| @ Baltimore Orioles | Oriole Park at Camden Yards | |
| @ Baltimore Orioles | Oriole Park at Camden Yards | |
| vs Los Angeles Angels | Comerica Park | |
| vs Los Angeles Angels | Comerica Park | |
| vs Los Angeles Angels | Comerica Park | |
| @ Chicago White Sox | Rate Field | |
| @ Chicago White Sox | Rate Field | |
| @ Chicago White Sox | Rate Field | |
| @ Tampa Bay Rays | Tropicana Field | |
| @ Tampa Bay Rays | Tropicana Field | |
| @ Tampa Bay Rays | Tropicana Field | |
| vs Seattle Mariners | Comerica Park | |
| vs Seattle Mariners | Comerica Park | |
| vs Seattle Mariners | Comerica Park | |
| vs Minnesota Twins | Comerica Park | |
| vs Minnesota Twins | Comerica Park | |
| vs Minnesota Twins | Comerica Park | |
| @ Cleveland Guardians | Progressive Field | |
| @ Cleveland Guardians | Progressive Field | |
| @ Cleveland Guardians | Progressive Field | |
| @ Houston Astros | Daikin Park | |
| @ Houston Astros | Daikin Park | |
| @ Houston Astros | Daikin Park | |
| vs Chicago White Sox | Comerica Park | |
| vs Chicago White Sox | Comerica Park | |
| vs Chicago White Sox | Comerica Park | |
| vs New York Yankees | Comerica Park | |
| vs New York Yankees | Comerica Park | |
| vs New York Yankees | Comerica Park | |
| vs Houston Astros | Comerica Park | |
| vs Houston Astros | Comerica Park | |
| vs Houston Astros | Comerica Park | |
| vs Houston Astros | Comerica Park | |
| @ New York Yankees | Yankee Stadium | |
| @ New York Yankees | Yankee Stadium | |
| @ New York Yankees | Yankee Stadium | |
| @ Texas Rangers | Globe Life Field | |
| @ Texas Rangers | Globe Life Field | |
| @ Texas Rangers | Globe Life Field | |
| vs Athletics | Comerica Park | |
| vs Athletics | Comerica Park | |
| vs Athletics | Comerica Park | |
| vs Philadelphia Phillies | Comerica Park | |
| vs Philadelphia Phillies | Comerica Park | |
| vs Philadelphia Phillies | Comerica Park | |
| @ Los Angeles Angels | Angel Stadium | |
| @ Los Angeles Angels | Angel Stadium | |
| @ Los Angeles Angels | Angel Stadium | |
| @ Chicago Cubs | Wrigley Field | |
| @ Chicago Cubs | Wrigley Field | |
| @ Chicago Cubs | Wrigley Field | |
| vs Kansas City Royals | Comerica Park | |
| vs Kansas City Royals | Comerica Park | |
| vs Kansas City Royals | Comerica Park | |
| vs Kansas City Royals | Comerica Park | |
| vs Baltimore Orioles | Comerica Park | |
| vs Baltimore Orioles | Comerica Park | |
| vs Baltimore Orioles | Comerica Park | |
| @ Athletics | Sutter Health Park | |
| @ Athletics | Sutter Health Park | |
| @ Athletics | Sutter Health Park | |
| @ Seattle Mariners | T-Mobile Park | |
| @ Seattle Mariners | T-Mobile Park | |
| @ Seattle Mariners | T-Mobile Park | |
| @ San Francisco Giants | Oracle Park | |
| @ San Francisco Giants | Oracle Park | |
| @ San Francisco Giants | Oracle Park | |
| vs Cleveland Guardians | Comerica Park | |
| vs Cleveland Guardians | Comerica Park | |
| vs Cleveland Guardians | Comerica Park | |
| vs Chicago White Sox | Comerica Park | |
| vs Chicago White Sox | Comerica Park | |
| vs Chicago White Sox | Comerica Park | |
| @ Pittsburgh Pirates | PNC Park | |
| @ Pittsburgh Pirates | PNC Park | |
| @ Pittsburgh Pirates | PNC Park | |
| @ Kansas City Royals | Kauffman Stadium | |
| @ Kansas City Royals | Kauffman Stadium | |
| @ Kansas City Royals | Kauffman Stadium | |
| vs Tampa Bay Rays | Comerica Park | |
| vs Tampa Bay Rays | Comerica Park | |
| vs Tampa Bay Rays | Comerica Park | |
| vs Los Angeles Dodgers | Comerica Park | |
| vs Los Angeles Dodgers | Comerica Park | |
| vs Los Angeles Dodgers | Comerica Park | |
| @ Minnesota Twins | Target Field | |
| @ Minnesota Twins | Target Field | |
| @ Minnesota Twins | Target Field | |
| @ Cleveland Guardians | Progressive Field | |
| @ Cleveland Guardians | Progressive Field | |
| @ Cleveland Guardians | Progressive Field | |
| vs Minnesota Twins | Comerica Park | |
| vs Minnesota Twins | Comerica Park | |
| vs Minnesota Twins | Comerica Park | |
| vs Colorado Rockies | Comerica Park | |
| vs Colorado Rockies | Comerica Park | |
| vs Colorado Rockies | Comerica Park | |
| @ Toronto Blue Jays | Rogers Centre | |
| @ Toronto Blue Jays | Rogers Centre | |
| @ Toronto Blue Jays | Rogers Centre | |
| @ Chicago White Sox | Rate Field | |
| @ Chicago White Sox | Rate Field | |
| @ Chicago White Sox | Rate Field | |
| @ Chicago White Sox | Rate Field | |
| vs Washington Nationals | Comerica Park | |
| vs Washington Nationals | Comerica Park | |
| vs Washington Nationals | Comerica Park | |
| vs Pittsburgh Pirates | Comerica Park | |
| vs Pittsburgh Pirates | Comerica Park | |
| vs Pittsburgh Pirates | Comerica Park |