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| Date | Matchup | Venue |
|---|---|---|
| @ Athletics | Hohokam Stadium | |
| vs Arizona Diamondbacks | Goodyear Ballpark | |
| @ Los Angeles Dodgers | Camelback Ranch | |
| vs Texas Rangers | Goodyear Ballpark | |
| @ Seattle Mariners | Peoria Stadium | |
| @ Chicago Cubs | Sloan Park | |
| vs Chicago White Sox | Goodyear Ballpark | |
| vs Colorado Rockies | Goodyear Ballpark | |
| @ Arizona Diamondbacks | Salt River Fields at Talking Stick | |
| @ Texas Rangers | Surprise Stadium | |
| vs Los Angeles Dodgers | Goodyear Ballpark | |
| @ Chicago White Sox | Camelback Ranch | |
| vs Los Angeles Angels | Goodyear Ballpark | |
| vs San Diego Padres | Goodyear Ballpark | |
| @ Colorado Rockies | Salt River Fields at Talking Stick | |
| @ Kansas City Royals | Surprise Stadium | |
| vs San Francisco Giants | Goodyear Ballpark | |
| vs Milwaukee Brewers | Goodyear Ballpark | |
| @ Los Angeles Angels | Tempe Diablo Stadium | |
| @ San Diego Padres | Peoria Stadium | |
| vs Athletics | Goodyear Ballpark | |
| vs Chicago Cubs | Goodyear Ballpark | |
| @ Cincinnati Reds | Goodyear Ballpark | |
| vs Kansas City Royals | Goodyear Ballpark | |
| vs Seattle Mariners | Goodyear Ballpark | |
| @ San Francisco Giants | Scottsdale Stadium | |
| vs Cincinnati Reds | Goodyear Ballpark | |
| @ Arizona Diamondbacks | Chase Field | |
| @ Arizona Diamondbacks | Chase Field | |
| @ Seattle Mariners | T-Mobile Park | |
| @ Seattle Mariners | T-Mobile Park | |
| @ Seattle Mariners | T-Mobile Park | |
| @ Seattle Mariners | T-Mobile Park | |
| @ Los Angeles Dodgers | Dodger Stadium | |
| @ Los Angeles Dodgers | Dodger Stadium | |
| @ Los Angeles Dodgers | Dodger Stadium | |
| vs Chicago Cubs | Progressive Field | |
| vs Chicago Cubs | Progressive Field | |
| vs Chicago Cubs | Progressive Field | |
| vs Kansas City Royals | Progressive Field | |
| vs Kansas City Royals | Progressive Field | |
| vs Kansas City Royals | Progressive Field | |
| @ Atlanta Braves | Truist Park | |
| @ Atlanta Braves | Truist Park | |
| @ Atlanta Braves | Truist Park | |
| @ St. Louis Cardinals | Busch Stadium | |
| @ St. Louis Cardinals | Busch Stadium | |
| @ St. Louis Cardinals | Busch Stadium | |
| vs Baltimore Orioles | Progressive Field | |
| vs Baltimore Orioles | Progressive Field | |
| vs Baltimore Orioles | Progressive Field | |
| vs Baltimore Orioles | Progressive Field | |
| vs Houston Astros | Progressive Field | |
| vs Houston Astros | Progressive Field | |
| vs Houston Astros | Progressive Field | |
| @ Toronto Blue Jays | Rogers Centre | |
| @ Toronto Blue Jays | Rogers Centre | |
| @ Toronto Blue Jays | Rogers Centre | |
| vs Tampa Bay Rays | Progressive Field | |
| vs Tampa Bay Rays | Progressive Field | |
| vs Tampa Bay Rays | Progressive Field | |
| @ Athletics | Sutter Health Park | |
| @ Athletics | Sutter Health Park | |
| @ Athletics | Sutter Health Park | |
| @ Kansas City Royals | Kauffman Stadium | |
| @ Kansas City Royals | Kauffman Stadium | |
| @ Kansas City Royals | Kauffman Stadium | |
| @ Kansas City Royals | Kauffman Stadium | |
| vs Minnesota Twins | Progressive Field | |
| vs Minnesota Twins | Progressive Field | |
| vs Minnesota Twins | Progressive Field | |
| vs Los Angeles Angels | Progressive Field | |
| vs Los Angeles Angels | Progressive Field | |
| vs Los Angeles Angels | Progressive Field | |
| vs Cincinnati Reds | Progressive Field | |
| vs Cincinnati Reds | Progressive Field | |
| vs Cincinnati Reds | Progressive Field | |
| @ Detroit Tigers | Comerica Park | |
| @ Detroit Tigers | Comerica Park | |
| @ Detroit Tigers | Comerica Park | |
| @ Detroit Tigers | Comerica Park | |
| @ Philadelphia Phillies | Citizens Bank Park | |
| @ Philadelphia Phillies | Citizens Bank Park | |
| @ Philadelphia Phillies | Citizens Bank Park | |
| vs Washington Nationals | Progressive Field | |
| vs Washington Nationals | Progressive Field | |
| vs Washington Nationals | Progressive Field | |
| vs Boston Red Sox | Progressive Field | |
| vs Boston Red Sox | Progressive Field | |
| vs Boston Red Sox | Progressive Field | |
| @ New York Yankees | Yankee Stadium | |
| @ New York Yankees | Yankee Stadium | |
| @ New York Yankees | Yankee Stadium | |
| @ Texas Rangers | Globe Life Field | |
| @ Texas Rangers | Globe Life Field | |
| @ Texas Rangers | Globe Life Field | |
| vs New York Yankees | Progressive Field | |
| vs New York Yankees | Progressive Field | |
| vs New York Yankees | Progressive Field | |
| vs Detroit Tigers | Progressive Field | |
| vs Detroit Tigers | Progressive Field | |
| vs Detroit Tigers | Progressive Field | |
| @ Milwaukee Brewers | American Family Field | |
| @ Milwaukee Brewers | American Family Field | |
| @ Milwaukee Brewers | American Family Field | |
| @ Houston Astros | Daikin Park | |
| @ Houston Astros | Daikin Park | |
| @ Houston Astros | Daikin Park | |
| @ Chicago White Sox | Rate Field | |
| @ Chicago White Sox | Rate Field | |
| @ Chicago White Sox | Rate Field | |
| vs Seattle Mariners | Progressive Field | |
| vs Seattle Mariners | Progressive Field | |
| vs Seattle Mariners | Progressive Field | |
| vs Texas Rangers | Progressive Field | |
| vs Texas Rangers | Progressive Field | |
| vs Texas Rangers | Progressive Field | |
| vs Chicago White Sox | Progressive Field | |
| vs Chicago White Sox | Progressive Field | |
| vs Chicago White Sox | Progressive Field | |
| vs Chicago White Sox | Progressive Field | |
| @ Minnesota Twins | Target Field | |
| @ Minnesota Twins | Target Field | |
| @ Minnesota Twins | Target Field | |
| @ Miami Marlins | loanDepot park | |
| @ Miami Marlins | loanDepot park | |
| @ Miami Marlins | loanDepot park | |
| vs Pittsburgh Pirates | Progressive Field | |
| vs Pittsburgh Pirates | Progressive Field | |
| vs Pittsburgh Pirates | Progressive Field | |
| vs Minnesota Twins | Progressive Field | |
| vs Minnesota Twins | Progressive Field | |
| vs Minnesota Twins | Progressive Field | |
| vs Minnesota Twins | Progressive Field | |
| @ Tampa Bay Rays | Tropicana Field | |
| @ Tampa Bay Rays | Tropicana Field | |
| @ Tampa Bay Rays | Tropicana Field | |
| @ Cincinnati Reds | Great American Ball Park | |
| @ Cincinnati Reds | Great American Ball Park | |
| @ Cincinnati Reds | Great American Ball Park | |
| vs Arizona Diamondbacks | Progressive Field | |
| vs Arizona Diamondbacks | Progressive Field | |
| vs Arizona Diamondbacks | Progressive Field | |
| vs New York Mets | Progressive Field | |
| vs New York Mets | Progressive Field | |
| vs New York Mets | Progressive Field | |
| @ Chicago White Sox | Rate Field | |
| @ Chicago White Sox | Rate Field | |
| @ Chicago White Sox | Rate Field | |
| @ Detroit Tigers | Comerica Park | |
| @ Detroit Tigers | Comerica Park | |
| @ Detroit Tigers | Comerica Park | |
| vs San Diego Padres | Progressive Field | |
| vs San Diego Padres | Progressive Field | |
| vs San Diego Padres | Progressive Field | |
| vs San Francisco Giants | Progressive Field | |
| vs San Francisco Giants | Progressive Field | |
| vs San Francisco Giants | Progressive Field | |
| @ Colorado Rockies | Coors Field | |
| @ Colorado Rockies | Coors Field | |
| @ Colorado Rockies | Coors Field | |
| @ Los Angeles Angels | Angel Stadium | |
| @ Los Angeles Angels | Angel Stadium | |
| @ Los Angeles Angels | Angel Stadium | |
| vs Kansas City Royals | Progressive Field | |
| vs Kansas City Royals | Progressive Field | |
| vs Kansas City Royals | Progressive Field | |
| vs Toronto Blue Jays | Progressive Field | |
| vs Toronto Blue Jays | Progressive Field | |
| vs Toronto Blue Jays | Progressive Field | |
| vs Detroit Tigers | Progressive Field | |
| vs Detroit Tigers | Progressive Field | |
| vs Detroit Tigers | Progressive Field | |
| @ Baltimore Orioles | Oriole Park at Camden Yards | |
| @ Baltimore Orioles | Oriole Park at Camden Yards | |
| @ Baltimore Orioles | Oriole Park at Camden Yards | |
| @ Minnesota Twins | Target Field | |
| @ Minnesota Twins | Target Field | |
| @ Minnesota Twins | Target Field | |
| vs Chicago White Sox | Progressive Field | |
| vs Chicago White Sox | Progressive Field | |
| vs Chicago White Sox | Progressive Field | |
| vs Athletics | Progressive Field | |
| vs Athletics | Progressive Field | |
| vs Athletics | Progressive Field | |
| @ Boston Red Sox | Fenway Park | |
| @ Boston Red Sox | Fenway Park | |
| @ Boston Red Sox | Fenway Park | |
| @ Kansas City Royals | Kauffman Stadium | |
| @ Kansas City Royals | Kauffman Stadium | |
| @ Kansas City Royals | Kauffman Stadium |