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| Date | Matchup | Venue |
|---|---|---|
| vs Detroit Tigers | Fenway Park | |
| vs New York Yankees | Fenway Park | |
| vs New York Yankees | Fenway Park | |
| vs New York Yankees | Fenway Park | |
| @ Baltimore Orioles | Oriole Park at Camden Yards | |
| @ Baltimore Orioles | Oriole Park at Camden Yards | |
| @ Baltimore Orioles | Oriole Park at Camden Yards | |
| @ Toronto Blue Jays | Rogers Centre | |
| @ Toronto Blue Jays | Rogers Centre | |
| @ Toronto Blue Jays | Rogers Centre | |
| vs Houston Astros | Fenway Park | |
| vs Houston Astros | Fenway Park | |
| vs Houston Astros | Fenway Park | |
| @ Detroit Tigers | Comerica Park | |
| @ Detroit Tigers | Comerica Park | |
| @ Detroit Tigers | Comerica Park | |
| vs Tampa Bay Rays | Fenway Park | |
| vs Tampa Bay Rays | Fenway Park | |
| vs Tampa Bay Rays | Fenway Park | |
| vs Tampa Bay Rays | Fenway Park | |
| vs Philadelphia Phillies | Fenway Park | |
| vs Philadelphia Phillies | Fenway Park | |
| vs Philadelphia Phillies | Fenway Park | |
| @ Atlanta Braves | Truist Park | |
| @ Atlanta Braves | Truist Park | |
| @ Atlanta Braves | Truist Park | |
| @ Kansas City Royals | Kauffman Stadium | |
| @ Kansas City Royals | Kauffman Stadium | |
| @ Kansas City Royals | Kauffman Stadium | |
| vs Minnesota Twins | Fenway Park | |
| vs Minnesota Twins | Fenway Park | |
| vs Minnesota Twins | Fenway Park | |
| vs Atlanta Braves | Fenway Park | |
| vs Atlanta Braves | Fenway Park | |
| vs Atlanta Braves | Fenway Park | |
| @ Cleveland Guardians | Progressive Field | |
| @ Cleveland Guardians | Progressive Field | |
| @ Cleveland Guardians | Progressive Field | |
| vs Baltimore Orioles Lou Gehrig Day | Fenway Park | |
| vs Baltimore Orioles | Fenway Park | |
| vs Baltimore Orioles | Fenway Park | |
| @ New York Yankees | Yankee Stadium | |
| @ New York Yankees | Yankee Stadium | |
| @ New York Yankees | Yankee Stadium | |
| @ Tampa Bay Rays | Tropicana Field | |
| @ Tampa Bay Rays | Tropicana Field | |
| @ Tampa Bay Rays | Tropicana Field | |
| vs Texas Rangers | Fenway Park | |
| vs Texas Rangers | Fenway Park | |
| vs Texas Rangers | Fenway Park | |
| vs Toronto Blue Jays | Fenway Park | |
| vs Toronto Blue Jays | Fenway Park | |
| vs Toronto Blue Jays | Fenway Park | |
| @ Seattle Mariners | T-Mobile Park | |
| @ Seattle Mariners | T-Mobile Park | |
| @ Seattle Mariners | T-Mobile Park | |
| @ Colorado Rockies | Coors Field | |
| @ Colorado Rockies | Coors Field | |
| @ Colorado Rockies | Coors Field | |
| vs New York Yankees | Fenway Park | |
| vs New York Yankees | Fenway Park | |
| vs New York Yankees | Fenway Park | |
| vs New York Yankees | Fenway Park | |
| vs Washington Nationals | Fenway Park | |
| vs Washington Nationals | Fenway Park | |
| vs Washington Nationals | Fenway Park | |
| @ Los Angeles Angels | Angel Stadium | |
| @ Los Angeles Angels | Angel Stadium | |
| @ Los Angeles Angels | Angel Stadium | |
| @ Chicago White Sox | Rate Field | |
| @ Chicago White Sox | Rate Field | |
| @ Chicago White Sox | Rate Field | |
| @ New York Mets | Citi Field | |
| @ New York Mets | Citi Field | |
| @ New York Mets | Citi Field | |
| vs Tampa Bay Rays | Fenway Park | |
| vs Tampa Bay Rays | Fenway Park | |
| vs Tampa Bay Rays | Fenway Park | |
| vs Baltimore Orioles | Fenway Park | |
| vs Baltimore Orioles | Fenway Park | |
| vs Baltimore Orioles | Fenway Park | |
| vs Toronto Blue Jays | Fenway Park | |
| vs Toronto Blue Jays | Fenway Park | |
| vs Toronto Blue Jays | Fenway Park | |
| @ Athletics | Sutter Health Park | |
| @ Athletics | Sutter Health Park | |
| @ Athletics | Sutter Health Park | |
| @ Athletics | Sutter Health Park | |
| @ Los Angeles Dodgers | UNIQLO Field at Dodger Stadium | |
| @ Los Angeles Dodgers | UNIQLO Field at Dodger Stadium | |
| @ Los Angeles Dodgers | UNIQLO Field at Dodger Stadium | |
| vs Chicago White Sox | Fenway Park | |
| vs Chicago White Sox | Fenway Park | |
| vs Chicago White Sox | Fenway Park | |
| vs Athletics | Fenway Park | |
| vs Athletics | Fenway Park | |
| vs Athletics | Fenway Park | |
| @ Toronto Blue Jays | Rogers Centre | |
| @ Toronto Blue Jays | Rogers Centre | |
| @ Toronto Blue Jays | Rogers Centre | |
| @ Toronto Blue Jays | Rogers Centre | |
| @ Pittsburgh Pirates | PNC Park | |
| @ Pittsburgh Pirates | PNC Park | |
| @ Pittsburgh Pirates | PNC Park | |
| vs Arizona Diamondbacks | Fenway Park | |
| vs Arizona Diamondbacks | Fenway Park | |
| vs Arizona Diamondbacks | Fenway Park | |
| vs San Francisco Giants | Fenway Park | |
| vs San Francisco Giants | Fenway Park | |
| vs San Francisco Giants | Fenway Park | |
| @ Miami Marlins | loanDepot park | |
| @ Miami Marlins | loanDepot park | |
| @ Miami Marlins | loanDepot park | |
| @ New York Yankees | Yankee Stadium | |
| @ New York Yankees | Yankee Stadium | |
| @ New York Yankees | Yankee Stadium | |
| vs Seattle Mariners | Fenway Park | |
| vs Seattle Mariners | Fenway Park | |
| vs Seattle Mariners | Fenway Park | |
| @ Baltimore Orioles | Oriole Park at Camden Yards | |
| @ Baltimore Orioles | Oriole Park at Camden Yards | |
| @ Baltimore Orioles | Oriole Park at Camden Yards | |
| @ Baltimore Orioles | Oriole Park at Camden Yards | |
| vs Los Angeles Angels | Fenway Park | |
| vs Los Angeles Angels | Fenway Park | |
| vs Los Angeles Angels | Fenway Park | |
| vs Kansas City Royals | Fenway Park | |
| vs Kansas City Royals | Fenway Park | |
| vs Kansas City Royals | Fenway Park | |
| @ Texas Rangers Roberto Clemente Day | Globe Life Field | |
| @ Texas Rangers | Globe Life Field | |
| @ Texas Rangers | Globe Life Field | |
| @ Tampa Bay Rays | Tropicana Field | |
| @ Tampa Bay Rays | Tropicana Field | |
| @ Tampa Bay Rays | Tropicana Field | |
| vs Cleveland Guardians | Fenway Park | |
| vs Cleveland Guardians | Fenway Park | |
| vs Cleveland Guardians | Fenway Park | |
| vs Chicago Cubs | Fenway Park | |
| vs Chicago Cubs | Fenway Park | |
| vs Chicago Cubs | Fenway Park | |