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| Date | Matchup | Venue |
|---|---|---|
| vs Chicago White Sox | Fenway Park | |
| vs Chicago White Sox | Fenway Park | |
| vs Chicago White Sox | Fenway Park | |
| vs Athletics | Fenway Park | |
| vs Athletics | Fenway Park | |
| vs Athletics | Fenway Park | |
| @ Toronto Blue Jays | Rogers Centre | |
| @ Toronto Blue Jays | Rogers Centre | |
| @ Toronto Blue Jays | Rogers Centre | |
| @ Toronto Blue Jays | Rogers Centre | |
| @ Pittsburgh Pirates | PNC Park | |
| @ Pittsburgh Pirates | PNC Park | |
| @ Pittsburgh Pirates | PNC Park | |
| vs Arizona Diamondbacks | Fenway Park | |
| vs Arizona Diamondbacks | Fenway Park | |
| vs Arizona Diamondbacks | Fenway Park | |
| vs San Francisco Giants | Fenway Park | |
| vs San Francisco Giants | Fenway Park | |
| vs San Francisco Giants | Fenway Park | |
| @ Miami Marlins | loanDepot park | |
| @ Miami Marlins | loanDepot park | |
| @ Miami Marlins | loanDepot park | |
| @ New York Yankees | Yankee Stadium | |
| @ New York Yankees Makeup of 6/6 PPD | Yankee Stadium | |
| @ New York Yankees | Yankee Stadium | |
| @ New York Yankees | Yankee Stadium | |
| vs Seattle Mariners | Fenway Park | |
| vs Seattle Mariners | Fenway Park | |
| vs Seattle Mariners | Fenway Park | |
| @ Baltimore Orioles | Oriole Park at Camden Yards | |
| @ Baltimore Orioles | Oriole Park at Camden Yards | |
| @ Baltimore Orioles | Oriole Park at Camden Yards | |
| @ Baltimore Orioles | Oriole Park at Camden Yards | |
| vs Los Angeles Angels | Fenway Park | |
| vs Los Angeles Angels | Fenway Park | |
| vs Los Angeles Angels | Fenway Park | |
| vs Kansas City Royals | Fenway Park | |
| vs Kansas City Royals | Fenway Park | |
| vs Kansas City Royals | Fenway Park | |
| @ Texas Rangers Roberto Clemente Day | Globe Life Field | |
| @ Texas Rangers | Globe Life Field | |
| @ Texas Rangers | Globe Life Field | |
| @ Tampa Bay Rays | Tropicana Field | |
| @ Tampa Bay Rays | Tropicana Field | |
| @ Tampa Bay Rays | Tropicana Field | |
| vs Cleveland Guardians | Fenway Park | |
| vs Cleveland Guardians | Fenway Park | |
| vs Cleveland Guardians | Fenway Park | |
| vs Chicago Cubs | Fenway Park | |
| vs Chicago Cubs | Fenway Park | |
| vs Chicago Cubs | Fenway Park |