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| Date | Matchup | Venue |
|---|---|---|
| @ Hull City | The MKM Stadium, Hull | |
| vs Ipswich Town | Old Trafford, Manchester | |
| @ Everton | Hill Dickinson Stadium, Liverpool | |
| vs Manchester City | Old Trafford, Manchester | |
| @ Fulham | Craven Cottage, London | |
| vs Tottenham Hotspur | Old Trafford, Manchester | |
| @ Leeds United | Elland Road, Leeds | |
| vs AFC Bournemouth | Old Trafford, Manchester | |
| @ Chelsea | Stamford Bridge, London | |
| vs Aston Villa | Old Trafford, Manchester | |
| @ Liverpool | Anfield, Liverpool | |
| vs Brentford | Old Trafford, Manchester | |
| @ Newcastle United | St. James' Park, Newcastle-upon-Tyne | |
| vs Coventry City | Old Trafford, Manchester | |
| @ Crystal Palace | Selhurst Park, London | |
| @ Arsenal | Emirates Stadium, London | |
| vs Nottingham Forest | Old Trafford, Manchester | |
| vs Sunderland | Old Trafford, Manchester | |
| @ Brighton & Hove Albion | American Express Stadium, Falmer | |
| vs Newcastle United | Old Trafford, Manchester | |
| @ Aston Villa | Villa Park, Birmingham | |
| vs Liverpool | Old Trafford, Manchester | |
| @ Brentford | Gtech Community Stadium, Brentford | |
| vs Chelsea | Old Trafford, Manchester | |
| vs Brighton & Hove Albion | Old Trafford, Manchester | |
| @ Nottingham Forest | The City Ground, Nottingham | |
| vs Arsenal | Old Trafford, Manchester | |
| @ Sunderland | Stadium of Light, Sunderland | |
| vs Everton | Old Trafford, Manchester | |
| @ Manchester City | Etihad Stadium, Manchester | |
| vs Hull City | Old Trafford, Manchester | |
| @ Ipswich Town | Portman Road, Ipswich | |
| vs Crystal Palace | Old Trafford, Manchester | |
| @ Coventry City | The Coventry Building Society Arena, Coventry | |
| @ AFC Bournemouth | Vitality Stadium, Bournemouth | |
| vs Leeds United | Old Trafford, Manchester | |
| @ Tottenham Hotspur | Tottenham Hotspur Stadium, London | |
| vs Fulham | Old Trafford, Manchester |