| Aug 22 | @ Hull City | The MKM Stadium, HullUSA Net, Universo |
| Aug 30 | vs Ipswich Town | Old Trafford, ManchesterUSA Net, Tele |
| Sep 6 | @ Everton | Hill Dickinson Stadium, LiverpoolUSA Net, Tele |
| Sep 13 | vs Manchester City | Old Trafford, ManchesterNBCSN, Peacock, Tele |
| Sep 20 | @ Fulham | Craven Cottage, LondonNBC, Tele |
| Oct 10 | vs Tottenham Hotspur | Old Trafford, ManchesterNBC, Tele |
| Oct 18 | @ Leeds United | Elland Road, LeedsUSA Net, Tele |
| Oct 25 | vs AFC Bournemouth | Old Trafford, ManchesterPeacock |
| Oct 31 | @ Chelsea | Stamford Bridge, LondonUSA Net, Tele |
| When | Matchup | Venue and broadcast |
|---|---|---|
| Nov 8 | vs Aston Villa | Old Trafford, ManchesterUSA Net, Tele |
| Nov 22 | @ Liverpool | Anfield, Liverpool |
| Nov 28 | vs Brentford | Old Trafford, Manchester |
| Dec 2 | @ Newcastle United | St. James' Park, Newcastle-upon-Tyne |
| Dec 5 | vs Coventry City | Old Trafford, Manchester |
| Dec 13 | @ Crystal Palace | Selhurst Park, London |
| Dec 20 | @ Arsenal | Emirates Stadium, London |
| Dec 27 | vs Nottingham Forest | Old Trafford, Manchester |
| Dec 30 | vs Sunderland | Old Trafford, Manchester |
| Jan 2 | @ Brighton & Hove Albion | American Express Stadium, Falmer |
| Jan 7 | vs Newcastle United | Old Trafford, Manchester |
| Jan 16 | @ Aston Villa | Villa Park, Birmingham |
| Jan 23 | vs Liverpool | Old Trafford, Manchester |
| Jan 30 | @ Brentford | Gtech Community Stadium, Brentford |
| Feb 6 | vs Chelsea | Old Trafford, Manchester |
| Feb 10 | vs Brighton & Hove Albion | Old Trafford, Manchester |
| Feb 20 | @ Nottingham Forest | The City Ground, Nottingham |
| Feb 27 | vs Arsenal | Old Trafford, Manchester |
| Mar 3 | @ Sunderland | Stadium of Light, Sunderland |
| Mar 13 | vs Everton | Old Trafford, Manchester |
| Mar 20 | @ Manchester City | Etihad Stadium, Manchester |
| Apr 10 | vs Hull City | Old Trafford, Manchester |
| Apr 17 | @ Ipswich Town | Portman Road, Ipswich |
| Apr 24 | vs Crystal Palace | Old Trafford, Manchester |
| May 1 | @ Coventry City | Coventry Building Society Arena, Coventry |
| May 8 | @ AFC Bournemouth | Vitality Stadium, Bournemouth |
| May 15 | vs Leeds United | Old Trafford, Manchester |
| May 23 | @ Tottenham Hotspur | Tottenham Hotspur Stadium, London |
| May 30 | vs Fulham | Old Trafford, Manchester |