| Aug 23 | @ Newcastle United | St. James' Park, Newcastle-upon-TyneUSA Net, Tele |
| Aug 29 | vs Nottingham Forest | Anfield, LiverpoolUSA Net, Universo |
| Sep 4 | @ Ipswich Town | Portman Road, IpswichUSA Net |
| Sep 12 | vs Fulham | Anfield, LiverpoolPeacock |
| Sep 20 | @ AFC Bournemouth | Vitality Stadium, BournemouthUSA Net, Tele |
| Oct 11 | vs Manchester City | Anfield, LiverpoolNBC, Tele |
| Oct 17 | @ Brentford | Gtech Community Stadium, BrentfordPeacock |
| Oct 25 | vs Brighton & Hove Albion | Anfield, LiverpoolPeacock |
| Nov 1 | vs Arsenal | Anfield, LiverpoolNBCSN, Tele, Peacock |
| When | Matchup | Venue and broadcast |
|---|---|---|
| Nov 8 | @ Crystal Palace | Selhurst Park, LondonPeacock |
| Nov 22 | vs Manchester United | Anfield, Liverpool |
| Nov 29 | @ Everton | Hill Dickinson Stadium, Liverpool |
| Dec 2 | vs Sunderland | Anfield, Liverpool |
| Dec 5 | @ Chelsea | Stamford Bridge, London |
| Dec 12 | vs Leeds United | Anfield, Liverpool |
| Dec 19 | vs Tottenham Hotspur | Anfield, Liverpool |
| Dec 26 | @ Hull City | The MKM Stadium, Hull |
| Dec 30 | @ Aston Villa | Villa Park, Birmingham |
| Jan 2 | vs Coventry City | Anfield, Liverpool |
| Jan 5 | @ Sunderland | Stadium of Light, Sunderland |
| Jan 16 | vs Crystal Palace | Anfield, Liverpool |
| Jan 23 | @ Manchester United | Old Trafford, Manchester |
| Jan 30 | vs Everton | Anfield, Liverpool |
| Feb 6 | @ Arsenal | Emirates Stadium, London |
| Feb 10 | @ Coventry City | Coventry Building Society Arena, Coventry |
| Feb 20 | vs Hull City | Anfield, Liverpool |
| Feb 27 | @ Tottenham Hotspur | Tottenham Hotspur Stadium, London |
| Mar 3 | vs Aston Villa | Anfield, Liverpool |
| Mar 13 | vs Ipswich Town | Anfield, Liverpool |
| Mar 20 | @ Fulham | Craven Cottage, London |
| Apr 10 | vs Newcastle United | Anfield, Liverpool |
| Apr 17 | @ Nottingham Forest | The City Ground, Nottingham |
| Apr 24 | @ Leeds United | Elland Road, Leeds |
| May 1 | vs Chelsea | Anfield, Liverpool |
| May 8 | @ Manchester City | Etihad Stadium, Manchester |
| May 15 | vs Brentford | Anfield, Liverpool |
| May 23 | @ Brighton & Hove Albion | American Express Stadium, Falmer |
| May 30 | vs AFC Bournemouth | Anfield, Liverpool |