| Aug 24 | vs Chelsea | Craven Cottage, LondonUSA Net, Universo |
| Aug 30 | @ Sunderland | Stadium of Light, SunderlandPeacock |
| Sep 5 | vs Crystal Palace | Craven Cottage, LondonPeacock |
| Sep 12 | @ Liverpool | Anfield, LiverpoolPeacock |
| Sep 20 | vs Manchester United | Craven Cottage, LondonNBC, Tele |
| Oct 10 | @ Ipswich Town | Portman Road, IpswichPeacock |
| Oct 17 | vs Hull City | Craven Cottage, LondonPeacock |
| Oct 24 | @ Coventry City | Coventry Building Society Arena, CoventryNBCSN, Peacock |
| Oct 31 | @ Aston Villa | Villa Park, BirminghamNBCSN, Peacock |
| When | Matchup | Venue and broadcast |
|---|---|---|
| Nov 7 | vs Newcastle United | Craven Cottage, LondonUSA Net, Peacock |
| Nov 21 | @ Manchester City | Etihad Stadium, Manchester |
| Nov 29 | vs AFC Bournemouth | Craven Cottage, London |
| Dec 3 | @ Tottenham Hotspur | Tottenham Hotspur Stadium, London |
| Dec 6 | @ Everton | Hill Dickinson Stadium, Liverpool |
| Dec 12 | vs Brentford | Craven Cottage, London |
| Dec 19 | @ Leeds United | Elland Road, Leeds |
| Dec 26 | vs Brighton & Hove Albion | Craven Cottage, London |
| Dec 30 | vs Arsenal | Craven Cottage, London |
| Jan 2 | @ Nottingham Forest | The City Ground, Nottingham |
| Jan 6 | vs Tottenham Hotspur | Craven Cottage, London |
| Jan 16 | @ Newcastle United | St. James' Park, Newcastle-upon-Tyne |
| Jan 23 | vs Aston Villa | Craven Cottage, London |
| Jan 30 | @ AFC Bournemouth | Vitality Stadium, Bournemouth |
| Feb 6 | vs Manchester City | Craven Cottage, London |
| Feb 10 | vs Nottingham Forest | Craven Cottage, London |
| Feb 20 | @ Arsenal | Emirates Stadium, London |
| Feb 27 | vs Leeds United | Craven Cottage, London |
| Mar 3 | @ Brighton & Hove Albion | American Express Stadium, Falmer |
| Mar 13 | @ Crystal Palace | Selhurst Park, London |
| Mar 20 | vs Liverpool | Craven Cottage, London |
| Apr 10 | @ Chelsea | Stamford Bridge, London |
| Apr 17 | vs Sunderland | Craven Cottage, London |
| Apr 24 | @ Brentford | Gtech Community Stadium, Brentford |
| May 1 | vs Everton | Craven Cottage, London |
| May 8 | vs Ipswich Town | Craven Cottage, London |
| May 15 | @ Hull City | The MKM Stadium, Hull |
| May 23 | vs Coventry City | Craven Cottage, London |
| May 30 | @ Manchester United | Old Trafford, Manchester |