| Aug 22 | @ Everton | Hill Dickinson Stadium, LiverpoolUSA Net, Universo |
| Aug 28 | vs Manchester City | Selhurst Park, LondonUSA Net |
| Sep 5 | @ Fulham | Craven Cottage, LondonPeacock |
| Sep 12 | vs Ipswich Town | Selhurst Park, LondonPeacock |
| Sep 20 | @ Leeds United | Elland Road, LeedsPeacock |
| Oct 11 | vs Nottingham Forest | Selhurst Park, LondonUSA Net, Universo |
| Oct 18 | @ Brighton & Hove Albion | American Express Stadium, FalmerPeacock |
| Oct 25 | vs Newcastle United | Selhurst Park, LondonUSA Net, Tele |
| Oct 31 | @ Tottenham Hotspur | Tottenham Hotspur Stadium, LondonNBC, Universo |
| When | Matchup | Venue and broadcast |
|---|---|---|
| Nov 8 | vs Liverpool | Selhurst Park, LondonPeacock |
| Nov 21 | @ Coventry City | Coventry Building Society Arena, Coventry |
| Nov 29 | vs Hull City | Selhurst Park, London |
| Dec 2 | @ Chelsea | Stamford Bridge, London |
| Dec 5 | @ Aston Villa | Villa Park, Birmingham |
| Dec 13 | vs Manchester United | Selhurst Park, London |
| Dec 20 | @ Sunderland | Stadium of Light, Sunderland |
| Dec 27 | vs Arsenal | Selhurst Park, London |
| Dec 30 | vs AFC Bournemouth | Selhurst Park, London |
| Jan 2 | @ Brentford | Gtech Community Stadium, Brentford |
| Jan 6 | vs Chelsea | Selhurst Park, London |
| Jan 16 | @ Liverpool | Anfield, Liverpool |
| Jan 23 | vs Tottenham Hotspur | Selhurst Park, London |
| Jan 30 | @ Hull City | The MKM Stadium, Hull |
| Feb 6 | vs Coventry City | Selhurst Park, London |
| Feb 10 | vs Brentford | Selhurst Park, London |
| Feb 20 | @ AFC Bournemouth | Vitality Stadium, Bournemouth |
| Feb 27 | vs Sunderland | Selhurst Park, London |
| Mar 3 | @ Arsenal | Emirates Stadium, London |
| Mar 13 | vs Fulham | Selhurst Park, London |
| Mar 20 | @ Ipswich Town | Portman Road, Ipswich |
| Apr 10 | vs Everton | Selhurst Park, London |
| Apr 17 | @ Manchester City | Etihad Stadium, Manchester |
| Apr 24 | @ Manchester United | Old Trafford, Manchester |
| May 1 | vs Aston Villa | Selhurst Park, London |
| May 8 | @ Nottingham Forest | The City Ground, Nottingham |
| May 15 | vs Brighton & Hove Albion | Selhurst Park, London |
| May 23 | @ Newcastle United | St. James' Park, Newcastle-upon-Tyne |
| May 30 | vs Leeds United | Selhurst Park, London |