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| Date | Matchup | Venue |
|---|---|---|
| vs Aston Villa | American Express Stadium, Falmer | |
| @ Chelsea | Stamford Bridge, London | |
| vs Leeds United | American Express Stadium, Falmer | |
| @ Coventry City | The Coventry Building Society Arena, Coventry | |
| vs Arsenal | American Express Stadium, Falmer | |
| @ Sunderland | Stadium of Light, Sunderland | |
| vs Crystal Palace | American Express Stadium, Falmer | |
| @ Liverpool | Anfield, Liverpool | |
| @ Manchester City | Etihad Stadium, Manchester | |
| vs Brentford | American Express Stadium, Falmer | |
| @ Hull City | The MKM Stadium, Hull | |
| vs Newcastle United | American Express Stadium, Falmer | |
| @ AFC Bournemouth | Vitality Stadium, Bournemouth | |
| @ Nottingham Forest | The City Ground, Nottingham | |
| vs Everton | American Express Stadium, Falmer | |
| vs Ipswich Town | American Express Stadium, Falmer | |
| @ Fulham | Craven Cottage, London | |
| @ Tottenham Hotspur | Tottenham Hotspur Stadium, London | |
| vs Manchester United | American Express Stadium, Falmer | |
| vs AFC Bournemouth | American Express Stadium, Falmer | |
| @ Brentford | Gtech Community Stadium, Brentford | |
| vs Manchester City | American Express Stadium, Falmer | |
| @ Newcastle United | St. James' Park, Newcastle-upon-Tyne | |
| vs Hull City | American Express Stadium, Falmer | |
| @ Manchester United | Old Trafford, Manchester | |
| vs Tottenham Hotspur | American Express Stadium, Falmer | |
| @ Ipswich Town | Portman Road, Ipswich | |
| vs Fulham | American Express Stadium, Falmer | |
| @ Leeds United | Elland Road, Leeds | |
| vs Coventry City | American Express Stadium, Falmer | |
| @ Aston Villa | Villa Park, Birmingham | |
| vs Chelsea | American Express Stadium, Falmer | |
| @ Everton | Hill Dickinson Stadium, Liverpool | |
| vs Nottingham Forest | American Express Stadium, Falmer | |
| vs Sunderland | American Express Stadium, Falmer | |
| @ Crystal Palace | Selhurst Park, London | |
| vs Liverpool | American Express Stadium, Falmer | |
| @ Arsenal | Emirates Stadium, London |