| Aug 21 | vs Coventry City | Emirates Stadium, LondonUSA Net, Universo |
| Aug 31 | @ Aston Villa | Villa Park, BirminghamUSA Net, Universo |
| Sep 6 | vs Chelsea | Emirates Stadium, LondonUSA Net, Tele |
| Sep 12 | @ Sunderland | Stadium of Light, SunderlandUSA Net, Tele |
| Sep 19 | @ Brighton & Hove Albion | American Express Stadium, FalmerUSA Net, Tele |
| Oct 10 | vs Leeds United | Emirates Stadium, LondonUSA Net, Universo |
| Oct 18 | @ Nottingham Forest | The City Ground, NottinghamPeacock |
| Oct 24 | vs Everton | Emirates Stadium, LondonUSA Net, Tele, Universo |
| Nov 1 | @ Liverpool | Anfield, LiverpoolNBCSN, Tele, Peacock |
| When | Matchup | Venue and broadcast |
|---|---|---|
| Nov 7 | vs Hull City | Emirates Stadium, LondonPeacock, Universo |
| Nov 21 | @ Newcastle United | St. James' Park, Newcastle-upon-Tyne |
| Nov 29 | vs Manchester City | Emirates Stadium, London |
| Dec 2 | @ Brentford | Gtech Community Stadium, Brentford |
| Dec 6 | @ Tottenham Hotspur | Tottenham Hotspur Stadium, London |
| Dec 13 | vs AFC Bournemouth | Emirates Stadium, London |
| Dec 20 | vs Manchester United | Emirates Stadium, London |
| Dec 27 | @ Crystal Palace | Selhurst Park, London |
| Dec 30 | @ Fulham | Craven Cottage, London |
| Jan 2 | vs Ipswich Town | Emirates Stadium, London |
| Jan 5 | vs Brentford | Emirates Stadium, London |
| Jan 16 | @ Hull City | The MKM Stadium, Hull |
| Jan 23 | vs Newcastle United | Emirates Stadium, London |
| Jan 30 | @ Manchester City | Etihad Stadium, Manchester |
| Feb 6 | vs Liverpool | Emirates Stadium, London |
| Feb 10 | @ Ipswich Town | Portman Road, Ipswich |
| Feb 20 | vs Fulham | Emirates Stadium, London |
| Feb 27 | @ Manchester United | Old Trafford, Manchester |
| Mar 3 | vs Crystal Palace | Emirates Stadium, London |
| Mar 13 | @ Chelsea | Stamford Bridge, London |
| Mar 20 | vs Sunderland | Emirates Stadium, London |
| Apr 10 | @ Coventry City | Coventry Building Society Arena, Coventry |
| Apr 17 | vs Aston Villa | Emirates Stadium, London |
| Apr 24 | @ AFC Bournemouth | Vitality Stadium, Bournemouth |
| May 1 | vs Tottenham Hotspur | Emirates Stadium, London |
| May 8 | @ Leeds United | Elland Road, Leeds |
| May 15 | vs Nottingham Forest | Emirates Stadium, London |
| May 23 | @ Everton | Hill Dickinson Stadium, Liverpool |
| May 30 | vs Brighton & Hove Albion | Emirates Stadium, London |