| Aug 17 | @ Cardiff City | Cardiff City Stadium, CardiffParamount+ |
| Aug 22 | vs Watford | STōK Cae Ras, WrexhamParamount+ |
| Aug 28 | vs Birmingham City | STōK Cae Ras, WrexhamParamount+ |
| Sep 2 | @ Millwall | The Den, LondonParamount+ |
| Sep 5 | @ Swansea City | Swansea.com Stadium, SwanseaParamount+ |
| Sep 8 | vs Burnley | STōK Cae Ras, WrexhamParamount+ |
| Sep 11 | @ West Ham United | London Stadium, LondonParamount+ |
| Sep 19 | vs Southampton | STōK Cae Ras, WrexhamParamount+ |
| Oct 10 | @ Derby County | Pride Park, DerbyParamount+ |
| Oct 13 | vs West Bromwich Albion | STōK Cae Ras, WrexhamParamount+ |
| Oct 17 | vs Preston North End | STōK Cae Ras, WrexhamParamount+ |
| Oct 24 | @ Blackburn Rovers | Ewood Park, BlackburnParamount+ |
| Oct 30 | @ Sheffield United | Bramall Lane, SheffieldParamount+ |
| Nov 4 | vs Middlesbrough | STōK Cae Ras, WrexhamParamount+ |
| When | Matchup | Venue and broadcast |
|---|---|---|
| Nov 7 | vs Wolverhampton Wanderers | STōK Cae Ras, WrexhamParamount+ |
| Nov 21 | @ Lincoln City | LNER Stadium, LincolnParamount+ |
| Nov 24 | @ Bristol City | Ashton Gate, Bristol |
| Nov 28 | vs Portsmouth | STōK Cae Ras, Wrexham |
| Dec 5 | @ Norwich City | Carrow Road, Norwich |
| Dec 8 | vs Charlton Athletic | STōK Cae Ras, Wrexham |
| Dec 11 | @ Bolton Wanderers | Toughsheet Community Stadium, Bolton |
| Dec 19 | vs Queens Park Rangers | STōK Cae Ras, Wrexham |
| Dec 26 | @ Stoke City | bet365 Stadium, Stoke-on-Trent |
| Dec 29 | vs Blackburn Rovers | STōK Cae Ras, Wrexham |
| Jan 1 | vs Bolton Wanderers | STōK Cae Ras, Wrexham |
| Jan 16 | @ Preston North End | Deepdale, Preston |
| Jan 23 | vs Sheffield United | STōK Cae Ras, Wrexham |
| Jan 27 | @ Middlesbrough | Riverside Stadium, Middlesbrough |
| Jan 30 | @ Wolverhampton Wanderers | Molineux Stadium, Wolverhampton |
| Feb 6 | vs Lincoln City | STōK Cae Ras, Wrexham |
| Feb 13 | vs West Ham United | STōK Cae Ras, Wrexham |
| Feb 16 | @ West Bromwich Albion | The Hawthorns, West Bromwich |
| Feb 20 | @ Southampton | St. Mary's Stadium, Southampton |
| Feb 27 | vs Derby County | STōK Cae Ras, Wrexham |
| Mar 2 | @ Watford | Vicarage Road, Watford |
| Mar 6 | vs Cardiff City | STōK Cae Ras, Wrexham |
| Mar 13 | @ Portsmouth | Fratton Park, Portsmouth |
| Mar 16 | vs Norwich City | STōK Cae Ras, Wrexham |
| Mar 20 | vs Stoke City | STōK Cae Ras, Wrexham |
| Apr 3 | @ Queens Park Rangers | MATRADE Loftus Road, London |
| Apr 6 | @ Burnley | Turf Moor, Burnley |
| Apr 10 | vs Swansea City | STōK Cae Ras, Wrexham |
| Apr 17 | @ Birmingham City | St. Andrew's Stadium, Birmingham |
| Apr 20 | vs Millwall | STōK Cae Ras, Wrexham |
| Apr 24 | @ Charlton Athletic | The Valley, London |
| May 1 | vs Bristol City | STōK Cae Ras, Wrexham |