| Aug 16 | @ Burnley | Turf Moor, BurnleyCBSSN, Paramount+ |
| Aug 22 | vs Charlton Athletic | London Stadium, LondonParamount+ |
| Aug 29 | @ Watford | Vicarage Road, WatfordParamount+ |
| Sep 1 | vs Wolverhampton Wanderers | London Stadium, LondonParamount+ |
| Sep 5 | vs Derby County | London Stadium, LondonParamount+ |
| Sep 8 | @ Bolton Wanderers | Toughsheet Community Stadium, BoltonParamount+ |
| Sep 11 | vs Wrexham | London Stadium, LondonParamount+ |
| Sep 19 | @ Millwall | The Den, LondonParamount+ |
| Oct 9 | vs Queens Park Rangers | London Stadium, LondonCBSSN, Paramount+ |
| Oct 14 | @ Lincoln City | LNER Stadium, LincolnParamount+ |
| Oct 17 | @ Swansea City | Swansea.com Stadium, SwanseaCBSSN, Paramount+ |
| Oct 24 | vs Southampton | London Stadium, LondonParamount+ |
| Oct 31 | vs West Bromwich Albion | London Stadium, LondonParamount+ |
| Nov 4 | @ Cardiff City | Cardiff City Stadium, CardiffParamount+ |
| When | Matchup | Venue and broadcast |
|---|---|---|
| Nov 7 | @ Blackburn Rovers | Ewood Park, BlackburnParamount+ |
| Nov 21 | vs Preston North End | London Stadium, LondonParamount+ |
| Nov 24 | @ Portsmouth | Fratton Park, Portsmouth |
| Nov 28 | vs Stoke City | London Stadium, London |
| Dec 4 | @ Sheffield United | Bramall Lane, Sheffield |
| Dec 8 | vs Middlesbrough | London Stadium, London |
| Dec 12 | vs Bristol City | London Stadium, London |
| Dec 19 | @ Birmingham City | St. Andrew's Stadium, Birmingham |
| Dec 26 | vs Norwich City | London Stadium, London |
| Dec 29 | @ Southampton | St. Mary's Stadium, Southampton |
| Jan 1 | @ Bristol City | Ashton Gate, Bristol |
| Jan 16 | vs Swansea City | London Stadium, London |
| Jan 23 | @ West Bromwich Albion | The Hawthorns, West Bromwich |
| Jan 27 | vs Cardiff City | London Stadium, London |
| Jan 30 | vs Blackburn Rovers | London Stadium, London |
| Feb 6 | @ Preston North End | Deepdale, Preston |
| Feb 13 | @ Wrexham | STōK Cae Ras, Wrexham |
| Feb 16 | vs Lincoln City | London Stadium, London |
| Feb 21 | vs Millwall | London Stadium, London |
| Feb 27 | @ Queens Park Rangers | MATRADE Loftus Road, London |
| Mar 2 | @ Charlton Athletic | The Valley, London |
| Mar 6 | vs Burnley | London Stadium, London |
| Mar 13 | @ Stoke City | bet365 Stadium, Stoke-on-Trent |
| Mar 17 | vs Sheffield United | London Stadium, London |
| Mar 20 | @ Norwich City | Carrow Road, Norwich |
| Apr 3 | vs Birmingham City | London Stadium, London |
| Apr 6 | vs Bolton Wanderers | London Stadium, London |
| Apr 10 | @ Derby County | Pride Park, Derby |
| Apr 17 | vs Watford | London Stadium, London |
| Apr 20 | @ Wolverhampton Wanderers | Molineux Stadium, Wolverhampton |
| Apr 24 | @ Middlesbrough | Riverside Stadium, Middlesbrough |
| May 1 | vs Portsmouth | London Stadium, London |