| Aug 16 | vs Southampton | Vicarage Road, WatfordParamount+ |
| Aug 22 | @ Wrexham | STōK Cae Ras, WrexhamParamount+ |
| Aug 29 | vs West Ham United | Vicarage Road, WatfordParamount+ |
| Sep 1 | @ Swansea City | Swansea.com Stadium, Swansea |
| Sep 5 | @ West Bromwich Albion | The Hawthorns, West BromwichParamount+ |
| Sep 8 | vs Preston North End | Vicarage Road, Watford |
| Sep 12 | vs Stoke City | Vicarage Road, WatfordParamount+ |
| Sep 18 | @ Bristol City | Ashton Gate, BristolParamount+ |
| Oct 10 | vs Burnley | Vicarage Road, WatfordParamount+ |
| Oct 13 | @ Cardiff City | Cardiff City Stadium, Cardiff |
| Oct 17 | vs Charlton Athletic | Vicarage Road, WatfordParamount+ |
| Oct 24 | @ Wolverhampton Wanderers | Molineux Stadium, WolverhamptonCBSSN, Paramount+ |
| Oct 31 | @ Norwich City | Carrow Road, Norwich |
| Nov 3 | vs Lincoln City | Vicarage Road, Watford |
| When | Matchup | Venue and broadcast |
|---|---|---|
| Nov 7 | vs Middlesbrough | Vicarage Road, WatfordParamount+ |
| Nov 21 | @ Sheffield United | Bramall Lane, Sheffield |
| Nov 25 | vs Blackburn Rovers | Vicarage Road, Watford |
| Nov 28 | @ Derby County | Pride Park, Derby |
| Dec 5 | vs Millwall | Vicarage Road, Watford |
| Dec 8 | @ Birmingham City | St. Andrew's Stadium, Birmingham |
| Dec 12 | @ Queens Park Rangers | MATRADE Loftus Road, London |
| Dec 19 | vs Bolton Wanderers | Vicarage Road, Watford |
| Dec 26 | @ Portsmouth | Fratton Park, Portsmouth |
| Dec 29 | vs Wolverhampton Wanderers | Vicarage Road, Watford |
| Jan 1 | vs Queens Park Rangers | Vicarage Road, Watford |
| Jan 16 | @ Charlton Athletic | The Valley, London |
| Jan 23 | vs Norwich City | Vicarage Road, Watford |
| Jan 26 | @ Lincoln City | LNER Stadium, Lincoln |
| Jan 30 | @ Middlesbrough | Riverside Stadium, Middlesbrough |
| Feb 6 | vs Sheffield United | Vicarage Road, Watford |
| Feb 13 | @ Stoke City | bet365 Stadium, Stoke-on-Trent |
| Feb 16 | vs Cardiff City | Vicarage Road, Watford |
| Feb 20 | vs Bristol City | Vicarage Road, Watford |
| Feb 27 | @ Burnley | Turf Moor, Burnley |
| Mar 2 | vs Wrexham | Vicarage Road, Watford |
| Mar 6 | @ Southampton | St. Mary's Stadium, Southampton |
| Mar 13 | vs Derby County | Vicarage Road, Watford |
| Mar 17 | @ Millwall | The Den, London |
| Mar 20 | vs Portsmouth | Vicarage Road, Watford |
| Apr 3 | @ Bolton Wanderers | Toughsheet Community Stadium, Bolton |
| Apr 7 | @ Preston North End | Deepdale, Preston |
| Apr 10 | vs West Bromwich Albion | Vicarage Road, Watford |
| Apr 17 | @ West Ham United | London Stadium, London |
| Apr 21 | vs Swansea City | Vicarage Road, Watford |
| Apr 24 | vs Birmingham City | Vicarage Road, Watford |
| May 1 | @ Blackburn Rovers | Ewood Park, Blackburn |