| Aug 15 | @ Bolton Wanderers | Toughsheet Community Stadium, BoltonParamount+ |
| Aug 22 | vs Wolverhampton Wanderers | Deepdale, PrestonCBSSN, Paramount+ |
| Aug 29 | @ Charlton Athletic | The Valley, London |
| Sep 1 | vs Bristol City | Deepdale, Preston |
| Sep 5 | vs Blackburn Rovers | Deepdale, PrestonParamount+ |
| Sep 8 | @ Watford | Vicarage Road, Watford |
| Sep 12 | vs Lincoln City | Deepdale, Preston |
| Sep 19 | @ Queens Park Rangers | MATRADE Loftus Road, London |
| Oct 10 | vs Millwall | Deepdale, PrestonParamount+ |
| Oct 13 | @ Birmingham City | St. Andrew's Stadium, Birmingham |
| Oct 17 | @ Wrexham | STōK Cae Ras, WrexhamParamount+ |
| Oct 24 | vs West Bromwich Albion | Deepdale, PrestonParamount+ |
| Oct 31 | @ Stoke City | bet365 Stadium, Stoke-on-TrentParamount+ |
| Nov 3 | vs Sheffield United | Deepdale, Preston |
| When | Matchup | Venue and broadcast |
|---|---|---|
| Nov 7 | vs Southampton | Deepdale, Preston |
| Nov 21 | @ West Ham United | London Stadium, LondonParamount+ |
| Nov 24 | @ Cardiff City | Cardiff City Stadium, Cardiff |
| Nov 28 | vs Norwich City | Deepdale, Preston |
| Dec 6 | @ Burnley | Turf Moor, Burnley |
| Dec 9 | vs Portsmouth | Deepdale, Preston |
| Dec 12 | vs Middlesbrough | Deepdale, Preston |
| Dec 19 | @ Swansea City | Swansea.com Stadium, Swansea |
| Dec 26 | vs Derby County | Deepdale, Preston |
| Dec 29 | @ West Bromwich Albion | The Hawthorns, West Bromwich |
| Jan 1 | @ Middlesbrough | Riverside Stadium, Middlesbrough |
| Jan 16 | vs Wrexham | Deepdale, Preston |
| Jan 23 | vs Stoke City | Deepdale, Preston |
| Jan 26 | @ Sheffield United | Bramall Lane, Sheffield |
| Jan 30 | @ Southampton | St. Mary's Stadium, Southampton |
| Feb 6 | vs West Ham United | Deepdale, Preston |
| Feb 13 | @ Lincoln City | LNER Stadium, Lincoln |
| Feb 16 | vs Birmingham City | Deepdale, Preston |
| Feb 20 | vs Queens Park Rangers | Deepdale, Preston |
| Feb 27 | @ Millwall | The Den, London |
| Mar 3 | @ Wolverhampton Wanderers | Molineux Stadium, Wolverhampton |
| Mar 6 | vs Bolton Wanderers | Deepdale, Preston |
| Mar 13 | @ Norwich City | Carrow Road, Norwich |
| Mar 16 | vs Burnley | Deepdale, Preston |
| Mar 20 | @ Derby County | Pride Park, Derby |
| Apr 3 | vs Swansea City | Deepdale, Preston |
| Apr 7 | vs Watford | Deepdale, Preston |
| Apr 10 | @ Blackburn Rovers | Ewood Park, Blackburn |
| Apr 17 | vs Charlton Athletic | Deepdale, Preston |
| Apr 21 | @ Bristol City | Ashton Gate, Bristol |
| Apr 24 | @ Portsmouth | Fratton Park, Portsmouth |
| May 1 | vs Cardiff City | Deepdale, Preston |