| Aug 15 | @ Bristol City | Ashton Gate, BristolParamount+ |
| Aug 22 | vs Norwich City | The Den, London |
| Aug 29 | @ Southampton | St. Mary's Stadium, SouthamptonParamount+ |
| Sep 2 | vs Wrexham | The Den, LondonParamount+ |
| Sep 5 | vs Bolton Wanderers | The Den, London |
| Sep 12 | @ Blackburn Rovers | Ewood Park, Blackburn |
| Sep 15 | @ Middlesbrough | Riverside Stadium, MiddlesbroughParamount+ |
| Sep 19 | vs West Ham United | The Den, LondonParamount+ |
| Oct 10 | @ Preston North End | Deepdale, PrestonParamount+ |
| Oct 13 | vs Swansea City | The Den, London |
| Oct 17 | vs Lincoln City | The Den, London |
| Oct 24 | @ Portsmouth | Fratton Park, PortsmouthCBSSN, Paramount+ |
| Oct 31 | vs Derby County | The Den, LondonParamount+ |
| Nov 3 | @ Birmingham City | St. Andrew's Stadium, BirminghamParamount+ |
| When | Matchup | Venue and broadcast |
|---|---|---|
| Nov 7 | @ West Bromwich Albion | The Hawthorns, West BromwichParamount+ |
| Nov 21 | vs Queens Park Rangers | The Den, LondonParamount+ |
| Nov 25 | @ Stoke City | bet365 Stadium, Stoke-on-Trent |
| Nov 28 | vs Burnley | The Den, London |
| Dec 5 | @ Watford | Vicarage Road, Watford |
| Dec 8 | vs Sheffield United | The Den, London |
| Dec 12 | @ Wolverhampton Wanderers | Molineux Stadium, Wolverhampton |
| Dec 19 | vs Charlton Athletic | The Den, London |
| Dec 26 | @ Cardiff City | Cardiff City Stadium, Cardiff |
| Dec 29 | vs Portsmouth | The Den, London |
| Jan 1 | vs Wolverhampton Wanderers | The Den, London |
| Jan 16 | @ Lincoln City | LNER Stadium, Lincoln |
| Jan 23 | @ Derby County | Pride Park, Derby |
| Jan 26 | vs Birmingham City | The Den, London |
| Jan 30 | vs West Bromwich Albion | The Den, London |
| Feb 6 | @ Queens Park Rangers | MATRADE Loftus Road, London |
| Feb 13 | vs Blackburn Rovers | The Den, London |
| Feb 17 | @ Swansea City | Swansea.com Stadium, Swansea |
| Feb 21 | @ West Ham United | London Stadium, London |
| Feb 27 | vs Preston North End | The Den, London |
| Mar 2 | @ Norwich City | Carrow Road, Norwich |
| Mar 6 | vs Bristol City | The Den, London |
| Mar 13 | @ Burnley | Turf Moor, Burnley |
| Mar 17 | vs Watford | The Den, London |
| Mar 20 | vs Cardiff City | The Den, London |
| Apr 3 | @ Charlton Athletic | The Valley, London |
| Apr 6 | vs Middlesbrough | The Den, London |
| Apr 10 | @ Bolton Wanderers | Toughsheet Community Stadium, Bolton |
| Apr 17 | vs Southampton | The Den, London |
| Apr 20 | @ Wrexham | STōK Cae Ras, Wrexham |
| Apr 24 | @ Sheffield United | Bramall Lane, Sheffield |
| May 1 | vs Stoke City | The Den, London |